Patterns of metastasis in women with metachronous contralateral breast cancer

V Vichapat; H Garmo; L Holmberg; I S Fentiman; A Tutt; C Gillett; M Lüchtenborg

doi:10.1038/bjc.2012.273

Patterns of metastasis in women with metachronous contralateral breast cancer

V Vichapat, H Garmo, L Holmberg, I S Fentiman, A Tutt, C Gillett, M Lüchtenborg

Comprehensive Cancer Centre

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Background: The understanding of metastatic patterns after metachronous contralateral breast cancer (CBC) may help determine the biological nature of CBC.

Methods: A cohort of 8478 women with breast cancer treated at Guy’s and St Thomas’ NHS Foundation Trust between 1975 and 2006 were studied. Organ-specific 5-year cumulative incidence and incidence rate ratios were assessed for women diagnosed with unilateral breast cancer (UBC), CBC within 5 years and CBC more than 5 years of the initial diagnosis.

Results: Women diagnosed with CBC within 5 years had a higher incidence of metastases in all organs compared with UBC. Women with a short interval time to CBC developed metastasis more rapidly and were more likely to develop visceral and distant cutaneous metastases compared with bone metastasis.

Conclusion: These findings explain poor prognosis of women with early occurring CBC and suggest that some of these CBCs are indicators of aggressive and/or systemic disease.

Original language	English
Pages (from-to)	221-223
Number of pages	3
Journal	BJC: British Journal of Cancer
Volume	107
Issue number	2
Early online date	26 Jun 2012
DOIs	https://doi.org/10.1038/bjc.2012.273
Publication status	Published - 10 Jul 2012

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abstract = "Background: The understanding of metastatic patterns after metachronous contralateral breast cancer (CBC) may help determine the biological nature of CBC.Methods: A cohort of 8478 women with breast cancer treated at Guy{\textquoteright}s and St Thomas{\textquoteright} NHS Foundation Trust between 1975 and 2006 were studied. Organ-specific 5-year cumulative incidence and incidence rate ratios were assessed for women diagnosed with unilateral breast cancer (UBC), CBC within 5 years and CBC more than 5 years of the initial diagnosis.Results: Women diagnosed with CBC within 5 years had a higher incidence of metastases in all organs compared with UBC. Women with a short interval time to CBC developed metastasis more rapidly and were more likely to develop visceral and distant cutaneous metastases compared with bone metastasis.Conclusion: These findings explain poor prognosis of women with early occurring CBC and suggest that some of these CBCs are indicators of aggressive and/or systemic disease.",

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doi = "10.1038/bjc.2012.273",

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T1 - Patterns of metastasis in women with metachronous contralateral breast cancer

AU - Vichapat, V

AU - Garmo, H

AU - Holmberg, L

AU - Fentiman, I S

AU - Tutt, A

AU - Gillett, C

AU - Lüchtenborg, M

PY - 2012/7/10

Y1 - 2012/7/10

N2 - Background: The understanding of metastatic patterns after metachronous contralateral breast cancer (CBC) may help determine the biological nature of CBC.Methods: A cohort of 8478 women with breast cancer treated at Guy’s and St Thomas’ NHS Foundation Trust between 1975 and 2006 were studied. Organ-specific 5-year cumulative incidence and incidence rate ratios were assessed for women diagnosed with unilateral breast cancer (UBC), CBC within 5 years and CBC more than 5 years of the initial diagnosis.Results: Women diagnosed with CBC within 5 years had a higher incidence of metastases in all organs compared with UBC. Women with a short interval time to CBC developed metastasis more rapidly and were more likely to develop visceral and distant cutaneous metastases compared with bone metastasis.Conclusion: These findings explain poor prognosis of women with early occurring CBC and suggest that some of these CBCs are indicators of aggressive and/or systemic disease.

AB - Background: The understanding of metastatic patterns after metachronous contralateral breast cancer (CBC) may help determine the biological nature of CBC.Methods: A cohort of 8478 women with breast cancer treated at Guy’s and St Thomas’ NHS Foundation Trust between 1975 and 2006 were studied. Organ-specific 5-year cumulative incidence and incidence rate ratios were assessed for women diagnosed with unilateral breast cancer (UBC), CBC within 5 years and CBC more than 5 years of the initial diagnosis.Results: Women diagnosed with CBC within 5 years had a higher incidence of metastases in all organs compared with UBC. Women with a short interval time to CBC developed metastasis more rapidly and were more likely to develop visceral and distant cutaneous metastases compared with bone metastasis.Conclusion: These findings explain poor prognosis of women with early occurring CBC and suggest that some of these CBCs are indicators of aggressive and/or systemic disease.

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DO - 10.1038/bjc.2012.273

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JF - BJC: British Journal of Cancer

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Patterns of metastasis in women with metachronous contralateral breast cancer

Abstract

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