Peripheral Hypoarousal but Not Preparation-Vigilance Impairment Endures in ADHD Remission

Sarah-Naomi James; Celeste H M Cheung; Anna-Sophie Rommel; Gráinne McLoughlin; Daniel Brandeis; Tobias Banaschewski; Philip Asherson; Jonna Kuntsi

doi:10.1177/1087054717698813

Peripheral Hypoarousal but Not Preparation-Vigilance Impairment Endures in ADHD Remission

Sarah-Naomi James, Celeste H M Cheung, Anna-Sophie Rommel, Gráinne McLoughlin, Daniel Brandeis, Tobias Banaschewski, Philip Asherson, Jonna Kuntsi

King's College London
1] BGI-Shenzhen, Shenzhen, China. [2] European Molecular Biology Laboratory, Heidelberg, Germany. [3] The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

Research output: Contribution to journal › Article › peer-review

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Abstract

OBJECTIVE: This study investigates whether impairments associated with persistent ADHD-impaired attention allocation (P3 amplitude), peripheral hypoarousal (skin conductance level [SCL]), and adjustment in preparatory state (contingent negative variation [CNV])-reflect enduring deficits unrelated to ADHD outcome or are markers of ADHD remission.

METHOD: Young people with childhood ADHD (73 persisters and 18 remitters) and 144 controls were compared on neurophysiological measures during two conditions (baseline and fast-incentive) of a four-choice reaction time task.

RESULTS: ADHD remitters differed from persisters, and were indistinguishable from controls, on baseline P3 amplitude and fast-incentive CNV amplitude ( p ≤ .05). ADHD remitters differed from controls ( p ≤ .01), and were indistinguishable from persisters ( p > .05), on baseline SCL.

CONCLUSION: Preparation-vigilance measures were markers of ADHD remission, confirming previous findings with other measures. Yet, SCL-measured peripheral hypoarousal emerges as an enduring deficit unrelated to ADHD improvement. Future studies should explore potential compensatory mechanisms that enable efficient preparation-vigilance processes in ADHD remitters.

Original language	English
Journal	Journal of Attention Disorders
Early online date	31 Mar 2017
DOIs	https://doi.org/10.1177/1087054717698813 https://doi.org/10.1177/1087054717698813
Publication status	Published - 31 May 2017

Keywords

ADHD
Remission
EEG
Arousal
Adolescents

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1087054717698813Licence: CC BY
10.1177/1087054717698813

Peripheral Hypoarousal but Not_JAMES_Publishedonline31March2017_GOLD VoR (CC-BY)Final published version, 363 KBLicence: CC BY

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title = "Peripheral Hypoarousal but Not Preparation-Vigilance Impairment Endures in ADHD Remission",

abstract = "OBJECTIVE: This study investigates whether impairments associated with persistent ADHD-impaired attention allocation (P3 amplitude), peripheral hypoarousal (skin conductance level [SCL]), and adjustment in preparatory state (contingent negative variation [CNV])-reflect enduring deficits unrelated to ADHD outcome or are markers of ADHD remission.METHOD: Young people with childhood ADHD (73 persisters and 18 remitters) and 144 controls were compared on neurophysiological measures during two conditions (baseline and fast-incentive) of a four-choice reaction time task.RESULTS: ADHD remitters differed from persisters, and were indistinguishable from controls, on baseline P3 amplitude and fast-incentive CNV amplitude ( p ≤ .05). ADHD remitters differed from controls ( p ≤ .01), and were indistinguishable from persisters ( p > .05), on baseline SCL.CONCLUSION: Preparation-vigilance measures were markers of ADHD remission, confirming previous findings with other measures. Yet, SCL-measured peripheral hypoarousal emerges as an enduring deficit unrelated to ADHD improvement. Future studies should explore potential compensatory mechanisms that enable efficient preparation-vigilance processes in ADHD remitters.",

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author = "Sarah-Naomi James and Cheung, {Celeste H M} and Anna-Sophie Rommel and Gr{\'a}inne McLoughlin and Daniel Brandeis and Tobias Banaschewski and Philip Asherson and Jonna Kuntsi",

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T1 - Peripheral Hypoarousal but Not Preparation-Vigilance Impairment Endures in ADHD Remission

AU - James, Sarah-Naomi

AU - Cheung, Celeste H M

AU - Rommel, Anna-Sophie

AU - McLoughlin, Gráinne

AU - Brandeis, Daniel

AU - Banaschewski, Tobias

AU - Asherson, Philip

AU - Kuntsi, Jonna

PY - 2017/5/31

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N2 - OBJECTIVE: This study investigates whether impairments associated with persistent ADHD-impaired attention allocation (P3 amplitude), peripheral hypoarousal (skin conductance level [SCL]), and adjustment in preparatory state (contingent negative variation [CNV])-reflect enduring deficits unrelated to ADHD outcome or are markers of ADHD remission.METHOD: Young people with childhood ADHD (73 persisters and 18 remitters) and 144 controls were compared on neurophysiological measures during two conditions (baseline and fast-incentive) of a four-choice reaction time task.RESULTS: ADHD remitters differed from persisters, and were indistinguishable from controls, on baseline P3 amplitude and fast-incentive CNV amplitude ( p ≤ .05). ADHD remitters differed from controls ( p ≤ .01), and were indistinguishable from persisters ( p > .05), on baseline SCL.CONCLUSION: Preparation-vigilance measures were markers of ADHD remission, confirming previous findings with other measures. Yet, SCL-measured peripheral hypoarousal emerges as an enduring deficit unrelated to ADHD improvement. Future studies should explore potential compensatory mechanisms that enable efficient preparation-vigilance processes in ADHD remitters.

AB - OBJECTIVE: This study investigates whether impairments associated with persistent ADHD-impaired attention allocation (P3 amplitude), peripheral hypoarousal (skin conductance level [SCL]), and adjustment in preparatory state (contingent negative variation [CNV])-reflect enduring deficits unrelated to ADHD outcome or are markers of ADHD remission.METHOD: Young people with childhood ADHD (73 persisters and 18 remitters) and 144 controls were compared on neurophysiological measures during two conditions (baseline and fast-incentive) of a four-choice reaction time task.RESULTS: ADHD remitters differed from persisters, and were indistinguishable from controls, on baseline P3 amplitude and fast-incentive CNV amplitude ( p ≤ .05). ADHD remitters differed from controls ( p ≤ .01), and were indistinguishable from persisters ( p > .05), on baseline SCL.CONCLUSION: Preparation-vigilance measures were markers of ADHD remission, confirming previous findings with other measures. Yet, SCL-measured peripheral hypoarousal emerges as an enduring deficit unrelated to ADHD improvement. Future studies should explore potential compensatory mechanisms that enable efficient preparation-vigilance processes in ADHD remitters.

KW - ADHD

KW - Remission

KW - EEG

KW - Arousal

KW - Adolescents

U2 - 10.1177/1087054717698813

DO - 10.1177/1087054717698813

M3 - Article

C2 - 28363258

SN - 1087-0547

JO - Journal of Attention Disorders

JF - Journal of Attention Disorders

ER -

Peripheral Hypoarousal but Not Preparation-Vigilance Impairment Endures in ADHD Remission

Abstract

Keywords

UN SDGs

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