PET Performance Evaluation of a pre-clinical SiPM based MR-compatible PET scanner

Jane E. Mackewn; Christoph W. Lerche; Kavitha Sunassee; Rafael T. M. de Rosales; Alkystis Phinikaridou; Andre Salomon; Richard Ayres; Charalampos Tsoumpas; Georgios M. Soultanidis; Tobias Schaeffter; Paul K. Marsden; Volkmar Schulz

doi:10.1109/NSSMIC.2012.6551633

PET Performance Evaluation of a pre-clinical SiPM based MR-compatible PET scanner

Jane E. Mackewn^*, Christoph W. Lerche, Kavitha Sunassee, Rafael T. M. de Rosales, Alkystis Phinikaridou, Andre Salomon, Richard Ayres, Charalampos Tsoumpas, Georgios M. Soultanidis, Tobias Schaeffter, Paul K. Marsden, Volkmar Schulz

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference paper

3 Citations (Scopus)

Abstract

We have carried out a PET performance evaluation of an SiPM based scanner designed for fully simultaneous preclinical PET/MR studies. The PET scanner has an inner diameter of 20 cm with a crystal size of 1.3 by 1.3 by 10 mm. The crystals are read out using MR-compatible SiPMs to allow the PET scanner to be located within a Philips 3T Achieva MRI scanner.

The spatial resolution of the system, measured using SSRB and 2D FBP is just under 2.4mm in the trans-axial and axial directions. The system sensitivity is 0.6 % for a point source at the centre of the field of view. The true coincidence count rate shows no sign of saturating at 30 MBq, at which point the randoms fraction is 9%, and the scatter fraction for a rat sized object is approximately 23%. Artefact-free images of phantoms have been obtained using SSRB/FBP and iterative reconstructions. The current performance is limited because only one of three axial ring positions is currently populated with detectors, and limitations of the first-generation detector readout ASIC used in the system.

The performance of the system as described is sufficient for imaging rat-sized animals and large organs within the mouse. We have demonstrated here the feasibility of using the system to investigate dynamic processes simultaneously in a mouse using PET and MR with a dual labeled PET/MR probe. Extrapolating from the current performance results we anticipate that population of all three detector rings and upgrading of the readout ASIC will result in an MR-compatible PET scanner with performance similar to that of state-of-the-art non-MR-compatible pre-clinical systems.

Original language	English
Title of host publication	2012 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC)
Editors	B Yu
Place of Publication	Piscataway, N.J.
Publisher	IEEE
Pages	2776-2779
Number of pages	4
Volume	N/A
Edition	N/A
ISBN (Print)	9781467320306
DOIs	https://doi.org/10.1109/NSSMIC.2012.6551633
Publication status	Published - 2012
Event	IEEE Nuclear Science Symposium / Medical Imaging Conference Record (NSS/MIC) / 19th Room-Temperature Semiconductor X-ray and Gamma-ray Detector Workshop - Anaheim, Canada Duration: 29 Oct 2012 → 3 Nov 2012

Publication series

Name	IEEE Nuclear Science Symposium Conference Record
Publisher	IEEE
ISSN (Print)	1082-3654

Conference

Conference	IEEE Nuclear Science Symposium / Medical Imaging Conference Record (NSS/MIC) / 19th Room-Temperature Semiconductor X-ray and Gamma-ray Detector Workshop
Country/Territory	Canada
Period	29/10/2012 → 3/11/2012

Access to Document

10.1109/NSSMIC.2012.6551633

Cite this

Mackewn, J. E., Lerche, C. W., Sunassee, K., de Rosales, R. T. M., Phinikaridou, A., Salomon, A., Ayres, R., Tsoumpas, C., Soultanidis, G. M., Schaeffter, T., Marsden, P. K., & Schulz, V. (2012). PET Performance Evaluation of a pre-clinical SiPM based MR-compatible PET scanner. In B. Yu (Ed.), 2012 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC) (N/A ed., Vol. N/A, pp. 2776-2779). (IEEE Nuclear Science Symposium Conference Record). IEEE. https://doi.org/10.1109/NSSMIC.2012.6551633

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title = "PET Performance Evaluation of a pre-clinical SiPM based MR-compatible PET scanner",

abstract = "We have carried out a PET performance evaluation of an SiPM based scanner designed for fully simultaneous preclinical PET/MR studies. The PET scanner has an inner diameter of 20 cm with a crystal size of 1.3 by 1.3 by 10 mm. The crystals are read out using MR-compatible SiPMs to allow the PET scanner to be located within a Philips 3T Achieva MRI scanner.The spatial resolution of the system, measured using SSRB and 2D FBP is just under 2.4mm in the trans-axial and axial directions. The system sensitivity is 0.6 % for a point source at the centre of the field of view. The true coincidence count rate shows no sign of saturating at 30 MBq, at which point the randoms fraction is 9%, and the scatter fraction for a rat sized object is approximately 23%. Artefact-free images of phantoms have been obtained using SSRB/FBP and iterative reconstructions. The current performance is limited because only one of three axial ring positions is currently populated with detectors, and limitations of the first-generation detector readout ASIC used in the system.The performance of the system as described is sufficient for imaging rat-sized animals and large organs within the mouse. We have demonstrated here the feasibility of using the system to investigate dynamic processes simultaneously in a mouse using PET and MR with a dual labeled PET/MR probe. Extrapolating from the current performance results we anticipate that population of all three detector rings and upgrading of the readout ASIC will result in an MR-compatible PET scanner with performance similar to that of state-of-the-art non-MR-compatible pre-clinical systems.",

author = "Mackewn, {Jane E.} and Lerche, {Christoph W.} and Kavitha Sunassee and {de Rosales}, {Rafael T. M.} and Alkystis Phinikaridou and Andre Salomon and Richard Ayres and Charalampos Tsoumpas and Soultanidis, {Georgios M.} and Tobias Schaeffter and Marsden, {Paul K.} and Volkmar Schulz",

year = "2012",

doi = "10.1109/NSSMIC.2012.6551633",

language = "English",

isbn = "9781467320306",

volume = "N/A",

series = "IEEE Nuclear Science Symposium Conference Record",

publisher = "IEEE",

pages = "2776--2779",

editor = "B Yu",

booktitle = "2012 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC)",

edition = "N/A",

note = "IEEE Nuclear Science Symposium / Medical Imaging Conference Record (NSS/MIC) / 19th Room-Temperature Semiconductor X-ray and Gamma-ray Detector Workshop ; Conference date: 29-10-2012 Through 03-11-2012",

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Mackewn, JE, Lerche, CW, Sunassee, K , de Rosales, RTM , Phinikaridou, A , Salomon, A, Ayres, R, Tsoumpas, C , Soultanidis, GM , Schaeffter, T , Marsden, PK & Schulz, V 2012, PET Performance Evaluation of a pre-clinical SiPM based MR-compatible PET scanner. in B Yu (ed.), 2012 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC). N/A edn, vol. N/A, IEEE Nuclear Science Symposium Conference Record, IEEE, Piscataway, N.J., pp. 2776-2779, IEEE Nuclear Science Symposium / Medical Imaging Conference Record (NSS/MIC) / 19th Room-Temperature Semiconductor X-ray and Gamma-ray Detector Workshop, Canada, 29/10/2012. https://doi.org/10.1109/NSSMIC.2012.6551633

PET Performance Evaluation of a pre-clinical SiPM based MR-compatible PET scanner. / Mackewn, Jane E.; Lerche, Christoph W.; Sunassee, Kavitha et al.
2012 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC). ed. / B Yu. Vol. N/A N/A. ed. Piscataway, N.J.: IEEE, 2012. p. 2776-2779 (IEEE Nuclear Science Symposium Conference Record).

Research output: Chapter in Book/Report/Conference proceeding › Conference paper

TY - CHAP

T1 - PET Performance Evaluation of a pre-clinical SiPM based MR-compatible PET scanner

AU - Mackewn, Jane E.

AU - Lerche, Christoph W.

AU - Sunassee, Kavitha

AU - de Rosales, Rafael T. M.

AU - Phinikaridou, Alkystis

AU - Salomon, Andre

AU - Ayres, Richard

AU - Tsoumpas, Charalampos

AU - Soultanidis, Georgios M.

AU - Schaeffter, Tobias

AU - Marsden, Paul K.

AU - Schulz, Volkmar

PY - 2012

Y1 - 2012

N2 - We have carried out a PET performance evaluation of an SiPM based scanner designed for fully simultaneous preclinical PET/MR studies. The PET scanner has an inner diameter of 20 cm with a crystal size of 1.3 by 1.3 by 10 mm. The crystals are read out using MR-compatible SiPMs to allow the PET scanner to be located within a Philips 3T Achieva MRI scanner.The spatial resolution of the system, measured using SSRB and 2D FBP is just under 2.4mm in the trans-axial and axial directions. The system sensitivity is 0.6 % for a point source at the centre of the field of view. The true coincidence count rate shows no sign of saturating at 30 MBq, at which point the randoms fraction is 9%, and the scatter fraction for a rat sized object is approximately 23%. Artefact-free images of phantoms have been obtained using SSRB/FBP and iterative reconstructions. The current performance is limited because only one of three axial ring positions is currently populated with detectors, and limitations of the first-generation detector readout ASIC used in the system.The performance of the system as described is sufficient for imaging rat-sized animals and large organs within the mouse. We have demonstrated here the feasibility of using the system to investigate dynamic processes simultaneously in a mouse using PET and MR with a dual labeled PET/MR probe. Extrapolating from the current performance results we anticipate that population of all three detector rings and upgrading of the readout ASIC will result in an MR-compatible PET scanner with performance similar to that of state-of-the-art non-MR-compatible pre-clinical systems.

AB - We have carried out a PET performance evaluation of an SiPM based scanner designed for fully simultaneous preclinical PET/MR studies. The PET scanner has an inner diameter of 20 cm with a crystal size of 1.3 by 1.3 by 10 mm. The crystals are read out using MR-compatible SiPMs to allow the PET scanner to be located within a Philips 3T Achieva MRI scanner.The spatial resolution of the system, measured using SSRB and 2D FBP is just under 2.4mm in the trans-axial and axial directions. The system sensitivity is 0.6 % for a point source at the centre of the field of view. The true coincidence count rate shows no sign of saturating at 30 MBq, at which point the randoms fraction is 9%, and the scatter fraction for a rat sized object is approximately 23%. Artefact-free images of phantoms have been obtained using SSRB/FBP and iterative reconstructions. The current performance is limited because only one of three axial ring positions is currently populated with detectors, and limitations of the first-generation detector readout ASIC used in the system.The performance of the system as described is sufficient for imaging rat-sized animals and large organs within the mouse. We have demonstrated here the feasibility of using the system to investigate dynamic processes simultaneously in a mouse using PET and MR with a dual labeled PET/MR probe. Extrapolating from the current performance results we anticipate that population of all three detector rings and upgrading of the readout ASIC will result in an MR-compatible PET scanner with performance similar to that of state-of-the-art non-MR-compatible pre-clinical systems.

U2 - 10.1109/NSSMIC.2012.6551633

DO - 10.1109/NSSMIC.2012.6551633

M3 - Conference paper

SN - 9781467320306

VL - N/A

T3 - IEEE Nuclear Science Symposium Conference Record

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BT - 2012 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC)

A2 - Yu, B

PB - IEEE

CY - Piscataway, N.J.

T2 - IEEE Nuclear Science Symposium / Medical Imaging Conference Record (NSS/MIC) / 19th Room-Temperature Semiconductor X-ray and Gamma-ray Detector Workshop

Y2 - 29 October 2012 through 3 November 2012

ER -

Mackewn JE, Lerche CW, Sunassee K , de Rosales RTM , Phinikaridou A , Salomon A et al. PET Performance Evaluation of a pre-clinical SiPM based MR-compatible PET scanner. In Yu B, editor, 2012 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC). N/A ed. Vol. N/A. Piscataway, N.J.: IEEE. 2012. p. 2776-2779. (IEEE Nuclear Science Symposium Conference Record). doi: 10.1109/NSSMIC.2012.6551633

PET Performance Evaluation of a pre-clinical SiPM based MR-compatible PET scanner

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