Pharmacogenetic prediction of clozapine response

M J Arranz; J Munro; J Birkett; A Bolonna; D Mancama; M Sodhi; K P Lesch; J F W Meyer; P Sham; D A Collier; R M Murray; R W Kerwin

doi:10.1016/S0140-6736(00)02221-2

Pharmacogenetic prediction of clozapine response

M J Arranz, J Munro, J Birkett, A Bolonna, D Mancama, M Sodhi, K P Lesch, J F W Meyer, P Sham, D A Collier, R M Murray, R W Kerwin

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Abstract

We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine In schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76.7% success in the prediction of clozapine response (p=0.0001) and a sensitivity of 95% (+/-0.04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.

Original language	English
Pages (from-to)	1615 - 1616
Number of pages	2
Journal	The Lancet
Volume	355
Issue number	9215
DOIs	https://doi.org/10.1016/S0140-6736(00)02221-2
Publication status	Published - 6 May 2000

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title = "Pharmacogenetic prediction of clozapine response",

abstract = "We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine In schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76.7% success in the prediction of clozapine response (p=0.0001) and a sensitivity of 95% (+/-0.04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.",

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T1 - Pharmacogenetic prediction of clozapine response

AU - Arranz, M J

AU - Munro, J

AU - Birkett, J

AU - Bolonna, A

AU - Mancama, D

AU - Sodhi, M

AU - Lesch, K P

AU - Meyer, J F W

AU - Sham, P

AU - Collier, D A

AU - Murray, R M

AU - Kerwin, R W

PY - 2000/5/6

Y1 - 2000/5/6

N2 - We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine In schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76.7% success in the prediction of clozapine response (p=0.0001) and a sensitivity of 95% (+/-0.04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.

AB - We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine In schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76.7% success in the prediction of clozapine response (p=0.0001) and a sensitivity of 95% (+/-0.04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.

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U2 - 10.1016/S0140-6736(00)02221-2

DO - 10.1016/S0140-6736(00)02221-2

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SN - 1474-547X

VL - 355

SP - 1615

EP - 1616

JO - The Lancet

JF - The Lancet

IS - 9215

ER -

Pharmacogenetic prediction of clozapine response

Abstract

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