TY - JOUR
T1 - Pharmacokinetic Modeling of Delayed Gadolinium Enhancement in the Myocardium
AU - Knowles, Benjamin R.
AU - Batchelor, Philip G.
AU - Parish, Victoria
AU - Ginks, Matthew
AU - Plein, Sven
AU - Razavi, Reza
AU - Schaeffter, Tobias
PY - 2008/12
Y1 - 2008/12
N2 - Delayed contrast-enhanced magnetic resonance imaging (DCE-MRI) provides prognostic information by delineating regions of myocardial scar. The mechanism of this delayed enhancement in myocardial infarctions (MIs) is hypothesized to result from altered kinetics and changes in the volumes of distribution in the myocardium. Pharmacokinetic models with two and three compartments were fitted to the concentration-time curves of dynamic contrast-enhanced MRI data obtained from five patients with known MI. Furthermore, the parameter stability was investigated in simulations for the two different models. The transfer constants and volumes of distribution showed a good correlation with imaging findings on early and delayed contrast-enhanced MRI. The two compartment model showed higher parameter stability. The three compartment model allows a more in-depth quantification of myocardial scarring. These models have the potential to improve the diagnosis of myocardial pathologies involving scar, with differing kinetics and volumes of distribution such as infarction or cardiomyopathy. Magn Reson Med 60:1524-1530, 2008. (C) 2008 Wiley-Liss, Inc.
AB - Delayed contrast-enhanced magnetic resonance imaging (DCE-MRI) provides prognostic information by delineating regions of myocardial scar. The mechanism of this delayed enhancement in myocardial infarctions (MIs) is hypothesized to result from altered kinetics and changes in the volumes of distribution in the myocardium. Pharmacokinetic models with two and three compartments were fitted to the concentration-time curves of dynamic contrast-enhanced MRI data obtained from five patients with known MI. Furthermore, the parameter stability was investigated in simulations for the two different models. The transfer constants and volumes of distribution showed a good correlation with imaging findings on early and delayed contrast-enhanced MRI. The two compartment model showed higher parameter stability. The three compartment model allows a more in-depth quantification of myocardial scarring. These models have the potential to improve the diagnosis of myocardial pathologies involving scar, with differing kinetics and volumes of distribution such as infarction or cardiomyopathy. Magn Reson Med 60:1524-1530, 2008. (C) 2008 Wiley-Liss, Inc.
U2 - 10.1002/mrm.21767
DO - 10.1002/mrm.21767
M3 - Article
SN - 1522-2594
VL - 60
SP - 1524
EP - 1530
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 6
ER -