TY - JOUR
T1 - Phenotypic plasticity in the pancreas: new triggers, new players
T2 - Cell Differentiation and DevelopmentCell Differentiation and Development
AU - Demcollari, Theoni Ingrid
AU - Cujba, Ana-Maria
AU - Sancho, Rocio
PY - 2017/12/31
Y1 - 2017/12/31
N2 - The pancreas has a very limited regenerative potential during homeostasis. Despite its quiescent nature, recent in vivo models suggest a certain degree of regeneration and cellular interconversion is possible within the adult pancreas. It has now become evident that cellular plasticity can be observed in essentially all cell types within the pancreas when provided with the right stress stimuli. In this review, we will focus on the latest findings uncovering phenotypic plasticity of different cell types in the pancreas, the molecular mechanisms behind such plasticity and how plasticity associated with pancreatic or non-pancreatic cells could be harnessed in the generation of new insulin-producing beta cells.
AB - The pancreas has a very limited regenerative potential during homeostasis. Despite its quiescent nature, recent in vivo models suggest a certain degree of regeneration and cellular interconversion is possible within the adult pancreas. It has now become evident that cellular plasticity can be observed in essentially all cell types within the pancreas when provided with the right stress stimuli. In this review, we will focus on the latest findings uncovering phenotypic plasticity of different cell types in the pancreas, the molecular mechanisms behind such plasticity and how plasticity associated with pancreatic or non-pancreatic cells could be harnessed in the generation of new insulin-producing beta cells.
U2 - 10.1016/j.ceb.2017.11.014
DO - 10.1016/j.ceb.2017.11.014
M3 - Article
SN - 0955-0674
VL - 49
SP - 38
EP - 46
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -