Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia

K. Smith-Jackson; M. R. Hentschke; C. E. Poli-De-Figueiredo; B. E. Pinheiro Da Costa; L. O. Kurlak; F. Broughton Pipkin; A. Czajka; H. D. Mistry

doi:10.1016/j.placenta.2015.02.001

Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia

K. Smith-Jackson, M. R. Hentschke, C. E. Poli-De-Figueiredo, B. E. Pinheiro Da Costa, L. O. Kurlak, F. Broughton Pipkin, A. Czajka, H. D. Mistry^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Abstract Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation.

Original language	English
Article number	3156
Pages (from-to)	607-610
Number of pages	4
Journal	Placenta
Volume	36
Issue number	5
DOIs	https://doi.org/10.1016/j.placenta.2015.02.001
Publication status	Published - 1 May 2015

Keywords

Caveolin
Cavin
Hypertension
Placenta
Pre-eclampsia

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title = "Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia",

abstract = "Abstract Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation.",

keywords = "Caveolin, Cavin, Hypertension, Placenta, Pre-eclampsia",

author = "K. Smith-Jackson and Hentschke, {M. R.} and Poli-De-Figueiredo, {C. E.} and {Pinheiro Da Costa}, {B. E.} and Kurlak, {L. O.} and {Broughton Pipkin}, F. and A. Czajka and Mistry, {H. D.}",

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doi = "10.1016/j.placenta.2015.02.001",

language = "English",

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T1 - Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia

AU - Smith-Jackson, K.

AU - Hentschke, M. R.

AU - Poli-De-Figueiredo, C. E.

AU - Pinheiro Da Costa, B. E.

AU - Kurlak, L. O.

AU - Broughton Pipkin, F.

AU - Czajka, A.

AU - Mistry, H. D.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Abstract Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation.

AB - Abstract Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation.

KW - Caveolin

KW - Cavin

KW - Hypertension

KW - Placenta

KW - Pre-eclampsia

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U2 - 10.1016/j.placenta.2015.02.001

DO - 10.1016/j.placenta.2015.02.001

M3 - Article

AN - SCOPUS:84927081247

SN - 0143-4004

VL - 36

SP - 607

EP - 610

JO - Placenta

JF - Placenta

IS - 5

M1 - 3156

ER -

Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia

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Keywords

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