Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction

Gunnar W. Reginsson; Andres Ingason; Jack Euesden; Gyda Bjornsdottir; Sigurgeir Olafsson; Engilbert Sigurdsson; Hogni Oskarsson; Thorarinn Tyrfingsson; Valgerdur Runarsdottir; Ingunn Hansdottir; Stacy Steinberg; Hreinn Stefansson; Daniel F. Gudbjartsson; Thorgeir E. Thorgeirsson; Kari Stefansson

doi:10.1111/adb.12496

Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction

Gunnar W. Reginsson, Andres Ingason, Jack Euesden, Gyda Bjornsdottir, Sigurgeir Olafsson, Engilbert Sigurdsson, Hogni Oskarsson, Thorarinn Tyrfingsson, Valgerdur Runarsdottir, Ingunn Hansdottir, Stacy Steinberg, Hreinn Stefansson, Daniel F. Gudbjartsson, Thorgeir E. Thorgeirsson, Kari Stefansson^*

^*Corresponding author for this work

Social Genetic & Developmental Psychiatry

Research output: Contribution to journal › Article › peer-review

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Abstract

We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in-patient addiction treatment and 35 754 smokers, we find that diagnoses of various substance use disorders and smoking associate strongly with PRSs for SCZ (P = 5.3 × 10^-50-1.4 × 10^-6) and BPD (P = 1.7 × 10^-9-1.9 × 10^-3), showing shared genetic etiology between psychosis and addiction. Using standardized scores for SCZ and BPD scaled to a unit increase doubling the risk of the corresponding disorder, the odds ratios for alcohol and substance use disorders range from 1.19 to 1.31 for the SCZ-PRS, and from 1.07 to 1.29 for the BPD-PRS. Furthermore, we show that as regular smoking becomes more stigmatized and less prevalent, these biological risk factors gain importance as determinants of the behavior.

Original language	English
Journal	Addiction Biology
Early online date	23 Feb 2017
DOIs	https://doi.org/10.1111/adb.12496
Publication status	E-pub ahead of print - 23 Feb 2017

Keywords

Polygenic scores
Psychotic disorders
Substance abuse

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/adb.12496

Polygenic risk scores for_REGINSSON_Publishedonline23February2017_GOLD VoRFinal published version, 430 KBLicence: CC BY-NC-ND

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Reginsson, G. W., Ingason, A., Euesden, J., Bjornsdottir, G., Olafsson, S., Sigurdsson, E., Oskarsson, H., Tyrfingsson, T., Runarsdottir, V., Hansdottir, I., Steinberg, S., Stefansson, H., Gudbjartsson, D. F., Thorgeirsson, T. E., & Stefansson, K. (2017). Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction. Addiction Biology. Advance online publication. https://doi.org/10.1111/adb.12496

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title = "Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction",

abstract = "We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in-patient addiction treatment and 35 754 smokers, we find that diagnoses of various substance use disorders and smoking associate strongly with PRSs for SCZ (P = 5.3 × 10-50-1.4 × 10-6) and BPD (P = 1.7 × 10-9-1.9 × 10-3), showing shared genetic etiology between psychosis and addiction. Using standardized scores for SCZ and BPD scaled to a unit increase doubling the risk of the corresponding disorder, the odds ratios for alcohol and substance use disorders range from 1.19 to 1.31 for the SCZ-PRS, and from 1.07 to 1.29 for the BPD-PRS. Furthermore, we show that as regular smoking becomes more stigmatized and less prevalent, these biological risk factors gain importance as determinants of the behavior.",

keywords = "Polygenic scores, Psychotic disorders, Substance abuse",

author = "Reginsson, {Gunnar W.} and Andres Ingason and Jack Euesden and Gyda Bjornsdottir and Sigurgeir Olafsson and Engilbert Sigurdsson and Hogni Oskarsson and Thorarinn Tyrfingsson and Valgerdur Runarsdottir and Ingunn Hansdottir and Stacy Steinberg and Hreinn Stefansson and Gudbjartsson, {Daniel F.} and Thorgeirsson, {Thorgeir E.} and Kari Stefansson",

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Reginsson, GW, Ingason, A, Euesden, J, Bjornsdottir, G, Olafsson, S, Sigurdsson, E, Oskarsson, H, Tyrfingsson, T, Runarsdottir, V, Hansdottir, I, Steinberg, S, Stefansson, H, Gudbjartsson, DF, Thorgeirsson, TE & Stefansson, K 2017, 'Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction', Addiction Biology. https://doi.org/10.1111/adb.12496

TY - JOUR

T1 - Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction

AU - Reginsson, Gunnar W.

AU - Ingason, Andres

AU - Euesden, Jack

AU - Bjornsdottir, Gyda

AU - Olafsson, Sigurgeir

AU - Sigurdsson, Engilbert

AU - Oskarsson, Hogni

AU - Tyrfingsson, Thorarinn

AU - Runarsdottir, Valgerdur

AU - Hansdottir, Ingunn

AU - Steinberg, Stacy

AU - Stefansson, Hreinn

AU - Gudbjartsson, Daniel F.

AU - Thorgeirsson, Thorgeir E.

AU - Stefansson, Kari

PY - 2017/2/23

Y1 - 2017/2/23

N2 - We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in-patient addiction treatment and 35 754 smokers, we find that diagnoses of various substance use disorders and smoking associate strongly with PRSs for SCZ (P = 5.3 × 10-50-1.4 × 10-6) and BPD (P = 1.7 × 10-9-1.9 × 10-3), showing shared genetic etiology between psychosis and addiction. Using standardized scores for SCZ and BPD scaled to a unit increase doubling the risk of the corresponding disorder, the odds ratios for alcohol and substance use disorders range from 1.19 to 1.31 for the SCZ-PRS, and from 1.07 to 1.29 for the BPD-PRS. Furthermore, we show that as regular smoking becomes more stigmatized and less prevalent, these biological risk factors gain importance as determinants of the behavior.

AB - We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in-patient addiction treatment and 35 754 smokers, we find that diagnoses of various substance use disorders and smoking associate strongly with PRSs for SCZ (P = 5.3 × 10-50-1.4 × 10-6) and BPD (P = 1.7 × 10-9-1.9 × 10-3), showing shared genetic etiology between psychosis and addiction. Using standardized scores for SCZ and BPD scaled to a unit increase doubling the risk of the corresponding disorder, the odds ratios for alcohol and substance use disorders range from 1.19 to 1.31 for the SCZ-PRS, and from 1.07 to 1.29 for the BPD-PRS. Furthermore, we show that as regular smoking becomes more stigmatized and less prevalent, these biological risk factors gain importance as determinants of the behavior.

KW - Polygenic scores

KW - Psychotic disorders

KW - Substance abuse

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U2 - 10.1111/adb.12496

DO - 10.1111/adb.12496

M3 - Article

AN - SCOPUS:85013635784

SN - 1355-6215

JO - Addiction Biology

JF - Addiction Biology

ER -

Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction

Abstract

Keywords

UN SDGs

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