Polyglutamine repeat length influences human androgen receptor/c-Jun mediated transcription

A J Grierson; R C Mootoosamy; C C J Miller

doi:10.1016/S0304-3940(99)00844-7

Polyglutamine repeat length influences human androgen receptor/c-Jun mediated transcription

A J Grierson, R C Mootoosamy, C C J Miller

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The androgen receptor and c-Jun are known to interact to modulate each others transcriptional activities. The androgen receptor contains a polymorphic polyglutamine repeat and expansion of this repeat to beyond approximately 40 causes spinobulbar muscular atrophy (SBMA; also known as Kennedy's disease), a genetic form of motor neurone disease. Here we show that the size of this polyglutamine tract influences both c-Jun regulation of androgen receptor-mediated transcription and androgen receptor regulation of c-Jun activity. c-Jun is a key mediator of neuronal survival and death by apoptosis. Inappropriate interactions between c-Jun and androgen receptors containing pathological length glutamine repeats may therefore be part of the pathogenic process in SBMA. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	9 - 12
Number of pages	4
Journal	Neuroscience Letters
Volume	277
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(99)00844-7
Publication status	Published - 17 Dec 1999

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AB - The androgen receptor and c-Jun are known to interact to modulate each others transcriptional activities. The androgen receptor contains a polymorphic polyglutamine repeat and expansion of this repeat to beyond approximately 40 causes spinobulbar muscular atrophy (SBMA; also known as Kennedy's disease), a genetic form of motor neurone disease. Here we show that the size of this polyglutamine tract influences both c-Jun regulation of androgen receptor-mediated transcription and androgen receptor regulation of c-Jun activity. c-Jun is a key mediator of neuronal survival and death by apoptosis. Inappropriate interactions between c-Jun and androgen receptors containing pathological length glutamine repeats may therefore be part of the pathogenic process in SBMA. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

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Polyglutamine repeat length influences human androgen receptor/c-Jun mediated transcription

Abstract

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