Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese

J J Shi; S Z Zhang; M N Tang; X H Liu; T Li; H Y Han; Y C Wang; Y B Guo; J H Zhao; H Li; C Ma

doi:10.1016/j.molbrainres.2003.10.018

Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese

J J Shi, S Z Zhang, M N Tang, X H Liu, T Li, H Y Han, Y C Wang, Y B Guo, J H Zhao, H Li, C Ma

Research output: Contribution to journal › Article › peer-review

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Abstract

The common polymorphism at codon 311 (C311S) of paraoxonase 2 gene (PON2) was investigated in 165 patients with sporadic late-onset Alzheimer's disease (LOAD) and 174 controls in Chinese. The PON2*C allele frequency was significantly increased in the patients as compared with controls. However, no significant difference was observed after stratification of apolipoprotein E (ApoE) epsilon4 allele. These results suggested that the PON2 polymorphism might be a risk factor for LOAD independent of ApoE epsilon4 status in Chinese. (C) 2003 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	201 - 204
Number of pages	4
Journal	Molecular Brain Research
Volume	120
Issue number	2
DOIs	https://doi.org/10.1016/j.molbrainres.2003.10.018
Publication status	Published - 5 Jan 2004

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10.1016/j.molbrainres.2003.10.018

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title = "Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese",

abstract = "The common polymorphism at codon 311 (C311S) of paraoxonase 2 gene (PON2) was investigated in 165 patients with sporadic late-onset Alzheimer's disease (LOAD) and 174 controls in Chinese. The PON2*C allele frequency was significantly increased in the patients as compared with controls. However, no significant difference was observed after stratification of apolipoprotein E (ApoE) epsilon4 allele. These results suggested that the PON2 polymorphism might be a risk factor for LOAD independent of ApoE epsilon4 status in Chinese. (C) 2003 Elsevier B.V. All rights reserved.",

author = "Shi, {J J} and Zhang, {S Z} and Tang, {M N} and Liu, {X H} and T Li and Han, {H Y} and Wang, {Y C} and Guo, {Y B} and Zhao, {J H} and H Li and C Ma",

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T1 - Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese

AU - Shi, J J

AU - Zhang, S Z

AU - Tang, M N

AU - Liu, X H

AU - Li, T

AU - Han, H Y

AU - Wang, Y C

AU - Guo, Y B

AU - Zhao, J H

AU - Li, H

AU - Ma, C

PY - 2004/1/5

Y1 - 2004/1/5

N2 - The common polymorphism at codon 311 (C311S) of paraoxonase 2 gene (PON2) was investigated in 165 patients with sporadic late-onset Alzheimer's disease (LOAD) and 174 controls in Chinese. The PON2*C allele frequency was significantly increased in the patients as compared with controls. However, no significant difference was observed after stratification of apolipoprotein E (ApoE) epsilon4 allele. These results suggested that the PON2 polymorphism might be a risk factor for LOAD independent of ApoE epsilon4 status in Chinese. (C) 2003 Elsevier B.V. All rights reserved.

AB - The common polymorphism at codon 311 (C311S) of paraoxonase 2 gene (PON2) was investigated in 165 patients with sporadic late-onset Alzheimer's disease (LOAD) and 174 controls in Chinese. The PON2*C allele frequency was significantly increased in the patients as compared with controls. However, no significant difference was observed after stratification of apolipoprotein E (ApoE) epsilon4 allele. These results suggested that the PON2 polymorphism might be a risk factor for LOAD independent of ApoE epsilon4 status in Chinese. (C) 2003 Elsevier B.V. All rights reserved.

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DO - 10.1016/j.molbrainres.2003.10.018

M3 - Article

SN - 1872-6941

VL - 120

SP - 201

EP - 204

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 2

ER -

Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese

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