Potential Hormone Mechanisms of Bariatric Surgery

Georgios K Dimitriadis; Manpal S Randeva; Alexander D Miras

doi:10.1007/s13679-017-0276-5

Potential Hormone Mechanisms of Bariatric Surgery

Georgios K Dimitriadis, Manpal S Randeva, Alexander D Miras

Diabetes

University of Warwick
Department of Materials, Imperial College London, London SW7 2AZ, United Kingdom; Department of Bioengineering, Imperial College London, London SW7 2AZ, United Kingdom; Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, United Kingdom.

Research output: Contribution to journal › Review article › peer-review

106 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: In recent years, the role of the gastrointestinal (GI) tract in energy homeostasis through modulation of the digestion and absorption of carbohydrates and the production of incretin hormones is well recognized.

RECENT FINDINGS: Bariatric surgery for obesity has been a very effective method in substantially improving weight, and numerous studies have focused on intestinal adaptation after bariatric procedures. A number of structural and functional changes in the GI tract have been reported postsurgery, which could be responsible for the altered hormonal responses. Furthermore, the change in food absorption rate and the intestinal regions exposed to carbohydrates may affect blood glucose response. This review hopes to give new insights into the direct role of gut hormones, by summarising the metabolic effects of bariatric surgery.

Original language	English
Pages (from-to)	253-265
Number of pages	13
Journal	Current obesity reports
Volume	6
Issue number	3
DOIs	https://doi.org/10.1007/s13679-017-0276-5
Publication status	Published - 1 Sept 2017

Keywords

Bariatric Surgery
Gastrointestinal Hormones/metabolism
Humans
Obesity, Morbid/metabolism
Weight Loss

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13679-017-0276-5

Cite this

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abstract = "PURPOSE OF REVIEW: In recent years, the role of the gastrointestinal (GI) tract in energy homeostasis through modulation of the digestion and absorption of carbohydrates and the production of incretin hormones is well recognized.RECENT FINDINGS: Bariatric surgery for obesity has been a very effective method in substantially improving weight, and numerous studies have focused on intestinal adaptation after bariatric procedures. A number of structural and functional changes in the GI tract have been reported postsurgery, which could be responsible for the altered hormonal responses. Furthermore, the change in food absorption rate and the intestinal regions exposed to carbohydrates may affect blood glucose response. This review hopes to give new insights into the direct role of gut hormones, by summarising the metabolic effects of bariatric surgery.",

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T1 - Potential Hormone Mechanisms of Bariatric Surgery

AU - Dimitriadis, Georgios K

AU - Randeva, Manpal S

AU - Miras, Alexander D

PY - 2017/9/1

Y1 - 2017/9/1

N2 - PURPOSE OF REVIEW: In recent years, the role of the gastrointestinal (GI) tract in energy homeostasis through modulation of the digestion and absorption of carbohydrates and the production of incretin hormones is well recognized.RECENT FINDINGS: Bariatric surgery for obesity has been a very effective method in substantially improving weight, and numerous studies have focused on intestinal adaptation after bariatric procedures. A number of structural and functional changes in the GI tract have been reported postsurgery, which could be responsible for the altered hormonal responses. Furthermore, the change in food absorption rate and the intestinal regions exposed to carbohydrates may affect blood glucose response. This review hopes to give new insights into the direct role of gut hormones, by summarising the metabolic effects of bariatric surgery.

AB - PURPOSE OF REVIEW: In recent years, the role of the gastrointestinal (GI) tract in energy homeostasis through modulation of the digestion and absorption of carbohydrates and the production of incretin hormones is well recognized.RECENT FINDINGS: Bariatric surgery for obesity has been a very effective method in substantially improving weight, and numerous studies have focused on intestinal adaptation after bariatric procedures. A number of structural and functional changes in the GI tract have been reported postsurgery, which could be responsible for the altered hormonal responses. Furthermore, the change in food absorption rate and the intestinal regions exposed to carbohydrates may affect blood glucose response. This review hopes to give new insights into the direct role of gut hormones, by summarising the metabolic effects of bariatric surgery.

KW - Bariatric Surgery

KW - Gastrointestinal Hormones/metabolism

KW - Humans

KW - Obesity, Morbid/metabolism

KW - Weight Loss

U2 - 10.1007/s13679-017-0276-5

DO - 10.1007/s13679-017-0276-5

M3 - Review article

C2 - 28780756

SN - 2162-4968

VL - 6

SP - 253

EP - 265

JO - Current obesity reports

JF - Current obesity reports

IS - 3

ER -

Potential Hormone Mechanisms of Bariatric Surgery

Abstract

Keywords

UN SDGs

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