Practical approaches to improving translatability and reproducibility in preclinical pain research

Nadia Soliman; Franziska Denk

doi:10.1016/j.bbi.2023.09.023

Practical approaches to improving translatability and reproducibility in preclinical pain research

Nadia Soliman, Franziska Denk

Wolfson SPaRC

Department of Materials, Imperial College London, London SW7 2AZ, United Kingdom; Department of Bioengineering, Imperial College London, London SW7 2AZ, United Kingdom; Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, United Kingdom.
1Department of Hepatology, Imperial College London, London, UK. 2Institute of Liver Studies at King's College School of Medicine at King's College Hospital, London, UK. 3Institute of Human Health and Performance, University College London, London, UK. 4Department of Asthma Allergy and Lung Biology, King's College London, London, UK. 5Division of Critical Care Medicine, University of Alberta, Edmonton, Canada.

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Pain research continues to face the challenge of poor translatability of pre-clinical studies. In this short primer, we are summarizing the possible causes, with an emphasis on practical and constructive solutions. In particular, we stress the importance of increased heterogeneity in animal studies; formal or informal pre-registration to combat publication bias; and increased statistical training in order to help pre-clinical scientists appreciate the usefulness of available experimental design and reporting guidelines.

Original language	English
Pages (from-to)	38-42
Number of pages	5
Journal	Brain, Behavior, and Immunity
Volume	115
DOIs	https://doi.org/10.1016/j.bbi.2023.09.023
Publication status	Published - Jan 2024

Keywords

Animals
Reproducibility of Results
Research Design
Pain

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10.1016/j.bbi.2023.09.023

Cite this

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title = "Practical approaches to improving translatability and reproducibility in preclinical pain research",

abstract = "Pain research continues to face the challenge of poor translatability of pre-clinical studies. In this short primer, we are summarizing the possible causes, with an emphasis on practical and constructive solutions. In particular, we stress the importance of increased heterogeneity in animal studies; formal or informal pre-registration to combat publication bias; and increased statistical training in order to help pre-clinical scientists appreciate the usefulness of available experimental design and reporting guidelines.",

keywords = "Animals, Reproducibility of Results, Research Design, Pain",

author = "Nadia Soliman and Franziska Denk",

note = "Funding Information: NS is a Jennie Gwynn post-doctoral career development fellow. FD is the recipient of a Medical Research Foundation Prize (MRF-160-0015-ELP-DENK-C0844). We would like to thank Prof Andrew Rice (AR) for his helpful comments on the manuscript. FD, AR and Prof Laura Stone ran a workshop at the International Association for the Study of Pain Meeting in Toronto 2022 which inspired this review. For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript (AAM) version arising from this submission. Publisher Copyright: {\textcopyright} 2023 The Author(s)",

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doi = "10.1016/j.bbi.2023.09.023",

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PY - 2024/1

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N2 - Pain research continues to face the challenge of poor translatability of pre-clinical studies. In this short primer, we are summarizing the possible causes, with an emphasis on practical and constructive solutions. In particular, we stress the importance of increased heterogeneity in animal studies; formal or informal pre-registration to combat publication bias; and increased statistical training in order to help pre-clinical scientists appreciate the usefulness of available experimental design and reporting guidelines.

AB - Pain research continues to face the challenge of poor translatability of pre-clinical studies. In this short primer, we are summarizing the possible causes, with an emphasis on practical and constructive solutions. In particular, we stress the importance of increased heterogeneity in animal studies; formal or informal pre-registration to combat publication bias; and increased statistical training in order to help pre-clinical scientists appreciate the usefulness of available experimental design and reporting guidelines.

KW - Animals

KW - Reproducibility of Results

KW - Research Design

KW - Pain

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DO - 10.1016/j.bbi.2023.09.023

M3 - Review article

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SP - 38

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JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

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Practical approaches to improving translatability and reproducibility in preclinical pain research

Abstract

Keywords

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