Preimplantation genetic diagnosis

P Braude; S Pickering; F Flinter; C Mackie Ogilvie

doi:10.1038/nrg953

Preimplantation genetic diagnosis

P Braude, S Pickering, F Flinter, C Mackie Ogilvie

Research output: Contribution to journal › Literature review › peer-review

221 Citations (Scopus)

Abstract

Preimplantation genetic diagnosis (PGD) is an evolving technique that provides a practical alternative to prenatal diagnosis and termination of pregnancy for couples who are at substantial risk of transmitting a serious genetic disorder to their offspring. Samples for genetic testing are obtained from oocytes or cleaving embryos after in vitro fertilization. Only embryos that are shown to be free of the genetic disorders are made available for replacement in the uterus, in the hope of establishing a pregnancy. PGD has provided unique insights into aspects of reproductive genetics and early human development, but has also raised important new ethical issues about assisted human reproduction.

Original language	English
Pages (from-to)	941 - 953
Number of pages	13
Journal	NATURE REVIEWS GENETICS
Volume	3
Issue number	12
DOIs	https://doi.org/10.1038/nrg953
Publication status	Published - 1 Dec 2002

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abstract = "Preimplantation genetic diagnosis (PGD) is an evolving technique that provides a practical alternative to prenatal diagnosis and termination of pregnancy for couples who are at substantial risk of transmitting a serious genetic disorder to their offspring. Samples for genetic testing are obtained from oocytes or cleaving embryos after in vitro fertilization. Only embryos that are shown to be free of the genetic disorders are made available for replacement in the uterus, in the hope of establishing a pregnancy. PGD has provided unique insights into aspects of reproductive genetics and early human development, but has also raised important new ethical issues about assisted human reproduction.",

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AU - Pickering, S

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AB - Preimplantation genetic diagnosis (PGD) is an evolving technique that provides a practical alternative to prenatal diagnosis and termination of pregnancy for couples who are at substantial risk of transmitting a serious genetic disorder to their offspring. Samples for genetic testing are obtained from oocytes or cleaving embryos after in vitro fertilization. Only embryos that are shown to be free of the genetic disorders are made available for replacement in the uterus, in the hope of establishing a pregnancy. PGD has provided unique insights into aspects of reproductive genetics and early human development, but has also raised important new ethical issues about assisted human reproduction.

U2 - 10.1038/nrg953

DO - 10.1038/nrg953

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JO - NATURE REVIEWS GENETICS

JF - NATURE REVIEWS GENETICS

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Preimplantation genetic diagnosis

Abstract

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