Preliminary specificity study of the Bestel-Clement-Sorine electromechanical model of the heart using parameter calibration from medical images

Patient-specific cardiac modelling can help in understanding pathophysiology and predict therapy effects. This requires the personalization of the geometry, kinematics, electrophysiology and mechanics. We use the Bestel-Clement-Sorine (BCS) electromechanical model of the heart, which provides reasonable accuracy with a reduced parameter number compared to the available clinical data at the organ level. We propose a preliminary specificity study to determine the relevant global parameters able to differentiate the pathological cases from the healthy controls. To this end, a calibration algorithm on global measurements is developed. This calibration method was tested successfully on 6 volunteers and 2 heart failure cases and enabled to tune up to 7 out of the 14 necessary parameters of the BCS model, from the volume and pressure curves. This specificity study confirmed domain-knowledge that the relaxation rate is impaired in post-myocardial infarction heart failure and the myocardial stiffness is increased in dilated cardiomyopathy heart failures.