TY - JOUR
T1 - Protein and genomic organisation of vertebrate MyoR and Capsulin genes and their expression during avian development
AU - von Scheven, G
AU - Bothe, I
AU - Ahmed, M U
AU - Alvares, L E
AU - Dietrich, S
PY - 2006/4
Y1 - 2006/4
N2 - The related bHLH transcription factors MyoR and Capsulin control craniofacial myogenesis and the development of a number of mesoderm-derived organs in the mouse. However, their molecular function as regulators of differentiation processes is conversely debated. One approach to clarify the roles of these genes is to comparatively analyse their biological and molecular function in various vertebrate models. For this, a prerequisite is the determination of their similarity and their expression patterns. Here we show that vertebrate MyoR and Capsulin are paralogous genes with a high level of conservation regarding their protein sequence, their cDNA sequence and their chromosomal organisation. In the chick, both genes are co-expressed in the developing branchiomeric muscles, the anterior heart field and the splanchnopleura lining the foregut. However, both genes show unique expression domains in trunk skeletal muscle precursors, in the lateral and intermediate mesoderm. (c) 2005 Elsevier B.V, All rights reserved
AB - The related bHLH transcription factors MyoR and Capsulin control craniofacial myogenesis and the development of a number of mesoderm-derived organs in the mouse. However, their molecular function as regulators of differentiation processes is conversely debated. One approach to clarify the roles of these genes is to comparatively analyse their biological and molecular function in various vertebrate models. For this, a prerequisite is the determination of their similarity and their expression patterns. Here we show that vertebrate MyoR and Capsulin are paralogous genes with a high level of conservation regarding their protein sequence, their cDNA sequence and their chromosomal organisation. In the chick, both genes are co-expressed in the developing branchiomeric muscles, the anterior heart field and the splanchnopleura lining the foregut. However, both genes show unique expression domains in trunk skeletal muscle precursors, in the lateral and intermediate mesoderm. (c) 2005 Elsevier B.V, All rights reserved
U2 - 10.1016/j.modgep.2005.09.008
DO - 10.1016/j.modgep.2005.09.008
M3 - Article
VL - 6
SP - 383
EP - 393
JO - Gene Expression Patterns
JF - Gene Expression Patterns
IS - 4
ER -