Protein disorder-order interplay to guide the growth of hierarchical mineralized structures

Sherif Elsharkawy; Maisoon Al-Jawad; Maria F. Pantano; Esther Tejeda-Montes; Khushbu Mehta; Hasan Jamal; Shweta Agarwal; Kseniya Shuturminska; Alistair Rice; Nadezda V. Tarakina; Rory M. Wilson; Andy J. Bushby; Matilde Alonso; Jose C. Rodriguez-Cabello; Ettore Barbieri; Armando Del Río Hernández; Molly M. Stevens; Nicola M. Pugno; Paul Anderson; Alvaro Mata

doi:10.1038/s41467-018-04319-0

Protein disorder-order interplay to guide the growth of hierarchical mineralized structures

Sherif Elsharkawy, Maisoon Al-Jawad, Maria F. Pantano, Esther Tejeda-Montes, Khushbu Mehta, Hasan Jamal, Shweta Agarwal, Kseniya Shuturminska, Alistair Rice, Nadezda V. Tarakina, Rory M. Wilson, Andy J. Bushby, Matilde Alonso, Jose C. Rodriguez-Cabello, Ettore Barbieri, Armando Del Río Hernández, Molly M. Stevens, Nicola M. Pugno, Paul Anderson, Alvaro Mata^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

A major goal in materials science is to develop bioinspired functional materials based on the precise control of molecular building blocks across length scales. Here we report a protein-mediated mineralization process that takes advantage of disorder-order interplay using elastin-like recombinamers to program organic-inorganic interactions into hierarchically ordered mineralized structures. The materials comprise elongated apatite nanocrystals that are aligned and organized into microscopic prisms, which grow together into spherulite-like structures hundreds of micrometers in diameter that come together to fill macroscopic areas. The structures can be grown over large uneven surfaces and native tissues as acid-resistant membranes or coatings with tuneable hierarchy, stiffness, and hardness. Our study represents a potential strategy for complex materials design that may open opportunities for hard tissue repair and provide insights into the role of molecular disorder in human physiology and pathology.

Original language	English
Article number	2145
Journal	Nature Communications
Volume	9
Issue number	1
Early online date	1 Jun 2018
DOIs	https://doi.org/10.1038/s41467-018-04319-0
Publication status	Published - Jun 2018

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10.1038/s41467-018-04319-0Licence: CC BY

Protein disorder–order_ELSHARKAWY_Accepted18April2018_GOLD VoRFinal published version, 5.41 MBLicence: CC BY

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Elsharkawy, S., Al-Jawad, M., Pantano, M. F., Tejeda-Montes, E., Mehta, K., Jamal, H., Agarwal, S., Shuturminska, K., Rice, A., Tarakina, N. V., Wilson, R. M., Bushby, A. J., Alonso, M., Rodriguez-Cabello, J. C., Barbieri, E., Del Río Hernández, A., Stevens, M. M., Pugno, N. M., Anderson, P., & Mata, A. (2018). Protein disorder-order interplay to guide the growth of hierarchical mineralized structures. Nature Communications, 9(1), Article 2145. https://doi.org/10.1038/s41467-018-04319-0

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title = "Protein disorder-order interplay to guide the growth of hierarchical mineralized structures",

abstract = "A major goal in materials science is to develop bioinspired functional materials based on the precise control of molecular building blocks across length scales. Here we report a protein-mediated mineralization process that takes advantage of disorder-order interplay using elastin-like recombinamers to program organic-inorganic interactions into hierarchically ordered mineralized structures. The materials comprise elongated apatite nanocrystals that are aligned and organized into microscopic prisms, which grow together into spherulite-like structures hundreds of micrometers in diameter that come together to fill macroscopic areas. The structures can be grown over large uneven surfaces and native tissues as acid-resistant membranes or coatings with tuneable hierarchy, stiffness, and hardness. Our study represents a potential strategy for complex materials design that may open opportunities for hard tissue repair and provide insights into the role of molecular disorder in human physiology and pathology.",

author = "Sherif Elsharkawy and Maisoon Al-Jawad and Pantano, {Maria F.} and Esther Tejeda-Montes and Khushbu Mehta and Hasan Jamal and Shweta Agarwal and Kseniya Shuturminska and Alistair Rice and Tarakina, {Nadezda V.} and Wilson, {Rory M.} and Bushby, {Andy J.} and Matilde Alonso and Rodriguez-Cabello, {Jose C.} and Ettore Barbieri and {Del R{\'i}o Hern{\'a}ndez}, Armando and Stevens, {Molly M.} and Pugno, {Nicola M.} and Paul Anderson and Alvaro Mata",

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Elsharkawy, S, Al-Jawad, M, Pantano, MF, Tejeda-Montes, E, Mehta, K, Jamal, H, Agarwal, S, Shuturminska, K, Rice, A, Tarakina, NV, Wilson, RM, Bushby, AJ, Alonso, M, Rodriguez-Cabello, JC, Barbieri, E, Del Río Hernández, A, Stevens, MM, Pugno, NM, Anderson, P & Mata, A 2018, 'Protein disorder-order interplay to guide the growth of hierarchical mineralized structures', Nature Communications, vol. 9, no. 1, 2145. https://doi.org/10.1038/s41467-018-04319-0

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AU - Elsharkawy, Sherif

AU - Al-Jawad, Maisoon

AU - Pantano, Maria F.

AU - Tejeda-Montes, Esther

AU - Mehta, Khushbu

AU - Jamal, Hasan

AU - Agarwal, Shweta

AU - Shuturminska, Kseniya

AU - Rice, Alistair

AU - Tarakina, Nadezda V.

AU - Wilson, Rory M.

AU - Bushby, Andy J.

AU - Alonso, Matilde

AU - Rodriguez-Cabello, Jose C.

AU - Barbieri, Ettore

AU - Del Río Hernández, Armando

AU - Stevens, Molly M.

AU - Pugno, Nicola M.

AU - Anderson, Paul

AU - Mata, Alvaro

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AB - A major goal in materials science is to develop bioinspired functional materials based on the precise control of molecular building blocks across length scales. Here we report a protein-mediated mineralization process that takes advantage of disorder-order interplay using elastin-like recombinamers to program organic-inorganic interactions into hierarchically ordered mineralized structures. The materials comprise elongated apatite nanocrystals that are aligned and organized into microscopic prisms, which grow together into spherulite-like structures hundreds of micrometers in diameter that come together to fill macroscopic areas. The structures can be grown over large uneven surfaces and native tissues as acid-resistant membranes or coatings with tuneable hierarchy, stiffness, and hardness. Our study represents a potential strategy for complex materials design that may open opportunities for hard tissue repair and provide insights into the role of molecular disorder in human physiology and pathology.

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SN - 2041-1723

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Protein disorder-order interplay to guide the growth of hierarchical mineralized structures

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