TY - JOUR
T1 - Psoriasis and cardiometabolic traits
T2 - Modest association but distinct genetic architectures
AU - Koch, Manja
AU - Baurecht, Hansjörg
AU - Ried, Janina S.
AU - Rodriguez, Elke
AU - Schlesinger, Sabrina
AU - Volks, Natalie
AU - Gieger, Christian
AU - Rückert, Ina Maria
AU - Heinrich, Luise
AU - Willenborg, Christina
AU - Smith, Catherine
AU - Peters, Annette
AU - Thorand, Barbara
AU - Koenig, Wolfgang
AU - Lamina, Claudia
AU - Jansen, Henning
AU - Kronenberg, Florian
AU - Seissler, Jochen
AU - Thiery, Joachim
AU - Rathmann, Wolfgang
AU - Schunkert, Heribert
AU - Erdmann, Jeanette
AU - Barker, Jonathan
AU - Nair, Rajan P.
AU - Tsoi, Lam C.
AU - Elder, James T.
AU - Mrowietz, Ulrich
AU - Weichenthal, Michael
AU - Mucha, Sören
AU - Schreiber, Stefan
AU - Franke, Andre
AU - Schmitt, Jochen
AU - Lieb, Wolfgang
AU - Weidinger, Stephan
PY - 2015/5/22
Y1 - 2015/5/22
N2 - Psoriasis has been linked to cardiometabolic diseases, but epidemiological findings are inconsistent. We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,098). A potential genetic overlap was explored using genome-wide data from >22,000 coronary artery disease and >4,000 psoriasis cases, and with a dense genotyping study of cardiometabolic risk loci on 927 psoriasis cases and 3,717 controls. After controlling for major confounders, in the cross-sectional analysis psoriasis was significantly associated with type 2 diabetes (T2D, adjusted odds ratio (OR)=2.36; 95% confidence interval CI=1.26-4.41) and myocardial infarction (MI, OR=2.26; 95% CI=1.03-4.96). In the longitudinal study, psoriasis slightly increased the risk for incident T2D (adjusted relative risk (RR)=1.11; 95% CI=1.08-1.14) and MI (RR=1.14; 95% CI=1.06-1.22), with highest risk increments in systemically treated psoriasis, which accounted for 11 and 17 excess cases of T2D and MI per 10,000 person-years. Except for weak signals from within the major histocompatibility complex, there was no evidence of genetic risk loci shared between psoriasis and cardiometabolic traits. Our findings suggest that psoriasis, in particular severe psoriasis, increases the risk for T2D and MI, and that the genetic architecture of psoriasis and cardiometabolic traits is largely distinct.
AB - Psoriasis has been linked to cardiometabolic diseases, but epidemiological findings are inconsistent. We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,098). A potential genetic overlap was explored using genome-wide data from >22,000 coronary artery disease and >4,000 psoriasis cases, and with a dense genotyping study of cardiometabolic risk loci on 927 psoriasis cases and 3,717 controls. After controlling for major confounders, in the cross-sectional analysis psoriasis was significantly associated with type 2 diabetes (T2D, adjusted odds ratio (OR)=2.36; 95% confidence interval CI=1.26-4.41) and myocardial infarction (MI, OR=2.26; 95% CI=1.03-4.96). In the longitudinal study, psoriasis slightly increased the risk for incident T2D (adjusted relative risk (RR)=1.11; 95% CI=1.08-1.14) and MI (RR=1.14; 95% CI=1.06-1.22), with highest risk increments in systemically treated psoriasis, which accounted for 11 and 17 excess cases of T2D and MI per 10,000 person-years. Except for weak signals from within the major histocompatibility complex, there was no evidence of genetic risk loci shared between psoriasis and cardiometabolic traits. Our findings suggest that psoriasis, in particular severe psoriasis, increases the risk for T2D and MI, and that the genetic architecture of psoriasis and cardiometabolic traits is largely distinct.
UR - http://www.scopus.com/inward/record.url?scp=84928419406&partnerID=8YFLogxK
U2 - 10.1038/jid.2015.8
DO - 10.1038/jid.2015.8
M3 - Article
AN - SCOPUS:84928419406
SN - 0022-202X
VL - 135
SP - 1283
EP - 1293
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 5
ER -
