Abstract
Background
Although evidence suggests that the EQ-5D and SF-6D have equivalent psychometric properties in people with depression, there is some evidence that the EQ-5D may lack responsiveness in certain populations with depression.
Aims
To examine the psychometric properties of the EQ-5D-5L and SF-6D measures of health-related quality of life in a representative sample of pregnant women with depression.
Method
Data were taken from a cohort of pregnant women identified at or soon after the first antenatal care contact and followed-up at three months post-partum. Health-related quality of life was measured using both the EQ-5D-5L and the SF-6D at baseline and follow-up. We examined acceptability and conducted psychometric validation in the aspects of concurrent validity, convergent validity, known-group validity, and responsiveness in 421 women with available data.
Results
The EQ-5D-5L and SF-6D have similarly high levels of acceptability. However, concurrent validation shows a lack of concordance between the EQ-5D-5L and SF-6D. The EQ-5D-5L tends to be higher than SF-6D in individuals with better health states. The SF-6D tends to be higher than EQ-5D-5L in individuals with poorer health states. Convergent and known-group validity are comparable between the two utility measures. Longitudinally, women who recovered show larger increase in SF-6D utilities than those who did not recover at follow-up. With the EQ-5D-5L, this is not the case. Additionally, the ceiling effects were more apparent in the EQ-5D-5L.
Conclusions
The effectiveness of perinatal mental health interventions may be better captured by SF-6D than EQ-5D-5L but this needs to be cross-validated in more studies.
Although evidence suggests that the EQ-5D and SF-6D have equivalent psychometric properties in people with depression, there is some evidence that the EQ-5D may lack responsiveness in certain populations with depression.
Aims
To examine the psychometric properties of the EQ-5D-5L and SF-6D measures of health-related quality of life in a representative sample of pregnant women with depression.
Method
Data were taken from a cohort of pregnant women identified at or soon after the first antenatal care contact and followed-up at three months post-partum. Health-related quality of life was measured using both the EQ-5D-5L and the SF-6D at baseline and follow-up. We examined acceptability and conducted psychometric validation in the aspects of concurrent validity, convergent validity, known-group validity, and responsiveness in 421 women with available data.
Results
The EQ-5D-5L and SF-6D have similarly high levels of acceptability. However, concurrent validation shows a lack of concordance between the EQ-5D-5L and SF-6D. The EQ-5D-5L tends to be higher than SF-6D in individuals with better health states. The SF-6D tends to be higher than EQ-5D-5L in individuals with poorer health states. Convergent and known-group validity are comparable between the two utility measures. Longitudinally, women who recovered show larger increase in SF-6D utilities than those who did not recover at follow-up. With the EQ-5D-5L, this is not the case. Additionally, the ceiling effects were more apparent in the EQ-5D-5L.
Conclusions
The effectiveness of perinatal mental health interventions may be better captured by SF-6D than EQ-5D-5L but this needs to be cross-validated in more studies.
| Original language | English |
|---|---|
| Article number | e88 |
| Journal | British Journal of Psychiatry Open |
| Volume | 5 |
| Issue number | 6 |
| Early online date | 7 Oct 2019 |
| DOIs | |
| Publication status | Published - 1 Nov 2019 |
Keywords
- EQ-5D
- Pregnancy
- SF-6D
- depression
- health-related quality of life
