Pulse Pileup Correction of Signals from a Pyroelectric Sensor for Phase-Insensitive Ultrasound Computed Tomography

This paper describes the application of a pulse pileup correction algorithm based on maximum likelihood estimation to simulated and experimentally acquired signals from a pyroelectric ultrasound sensor. The sensor forms part of a prototype phase-insensitive ultrasound computed tomography (piUCT) system for breast cancer detection that generates quantitative maps of acoustic attenuation. The effectiveness of the piUCT technique has been previously demonstrated through imaging of cylindrical, polyurethane phantoms. For the technique to be applied clinically, the system must be capable of measuring high acoustic attenuations (>30 dB) and completing a scan in a clinically acceptable time frame of approximately 5 min. High attenuations present a challenge because the sensor responds directly to acoustic power and therefore, an attenuation of 30 dB causes a drop in signal level of three orders of magnitude, resulting in a large dynamic range in the received signal set. Completion of a scan in 5 min requires a period between measurements shorter than the response time of the sensor, causing pyroelectric pulse pileup. The maximum likelihood estimation method recovers the amplitudes of closely spaced superimposed pyroelectric signals while improving the coefficient of variation of the measurement by a factor of two compared to direct pulse amplitude measurement, simultaneously increasing the maximum measurable attenuation and measurement rate of the system.