Qualification of the Seven Dementias Platform UK PET-MR Scanners for Multicentre Trials

Georgios Krokos; Jane MacKewn; Lucy Pike; William Hallett; Pawel Markiewicz; Anna Barnes; Marilena Rega; Tim D. Fryer; Roido Manavaki; Jose M. Anton-Rodriguez; Elizabeth Howell; Catriona Wimberley; Tim Clark; Gillian MacNaught; Paul Marsden; Julian C. Matthews

doi:10.1109/NSS/MIC42101.2019.9059802

Qualification of the Seven Dementias Platform UK PET-MR Scanners for Multicentre Trials

Georgios Krokos^*, Jane MacKewn, Lucy Pike, William Hallett, Pawel Markiewicz, Anna Barnes, Marilena Rega, Tim D. Fryer, Roido Manavaki, Jose M. Anton-Rodriguez, Elizabeth Howell, Catriona Wimberley, Tim Clark, Gillian MacNaught, Paul Marsden, Julian C. Matthews

^*Corresponding author for this work

PET Imaging Centre Facility

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

1 Citation (Scopus)

Abstract

Standardisation of PET scanners participating in multicentre trials is important in achieving reliable results and in maximizing the power of the study. The first multicentre clinical trial studies involving seven PET-MR scanners in the UK (four GE SIGNA and three Siemens mMR) are underway, led by Dementias Platform UK. In this study, the qualification of the seven scanners was tested using the NEMA image quality phantom. Consistent scanning methodology was followed across all sites with a 5:1 sphere-to-background contrast ratio and a CT-based μ-map used for attenuation correction. The reconstruction parameters were consistent between scanners of the same manufacturer. The SUVmean and SUVmax for all spheres were comparable between all scanners and within EARL performance specifications. Moreover, the averaged SUV values from all scanners were similar with the averaged corresponding values from 25 PET-CT scanners across the UK currently eligible to participate in multicentre trials. In conclusion, these preliminary results support the reliable comparison of PET performance across the PET-MR scanners.

Original language	English
Title of host publication	2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781728141640
DOIs	https://doi.org/10.1109/NSS/MIC42101.2019.9059802
Publication status	Published - Oct 2019
Event	2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019 - Manchester, United Kingdom Duration: 26 Oct 2019 → 2 Nov 2019

Publication series

Name	2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019

Conference

Conference	2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019
Country/Territory	United Kingdom
City	Manchester
Period	26/10/2019 → 2/11/2019

Keywords

Dementias Platform UK
NEMA phantom
PET-MR
quality control
standardization

Access to Document

10.1109/NSS/MIC42101.2019.9059802

Cite this

Krokos, G., MacKewn, J., Pike, L., Hallett, W., Markiewicz, P., Barnes, A., Rega, M., Fryer, T. D., Manavaki, R., Anton-Rodriguez, J. M., Howell, E., Wimberley, C., Clark, T., MacNaught, G., Marsden, P., & Matthews, J. C. (2019). Qualification of the Seven Dementias Platform UK PET-MR Scanners for Multicentre Trials. In 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019 Article 9059802 (2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSS/MIC42101.2019.9059802

Krokos, Georgios ; MacKewn, Jane ; Pike, Lucy et al. / Qualification of the Seven Dementias Platform UK PET-MR Scanners for Multicentre Trials. 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. (2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019).

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abstract = "Standardisation of PET scanners participating in multicentre trials is important in achieving reliable results and in maximizing the power of the study. The first multicentre clinical trial studies involving seven PET-MR scanners in the UK (four GE SIGNA and three Siemens mMR) are underway, led by Dementias Platform UK. In this study, the qualification of the seven scanners was tested using the NEMA image quality phantom. Consistent scanning methodology was followed across all sites with a 5:1 sphere-to-background contrast ratio and a CT-based μ-map used for attenuation correction. The reconstruction parameters were consistent between scanners of the same manufacturer. The SUVmean and SUVmax for all spheres were comparable between all scanners and within EARL performance specifications. Moreover, the averaged SUV values from all scanners were similar with the averaged corresponding values from 25 PET-CT scanners across the UK currently eligible to participate in multicentre trials. In conclusion, these preliminary results support the reliable comparison of PET performance across the PET-MR scanners.",

keywords = "Dementias Platform UK, NEMA phantom, PET-MR, quality control, standardization",

author = "Georgios Krokos and Jane MacKewn and Lucy Pike and William Hallett and Pawel Markiewicz and Anna Barnes and Marilena Rega and Fryer, {Tim D.} and Roido Manavaki and Anton-Rodriguez, {Jose M.} and Elizabeth Howell and Catriona Wimberley and Tim Clark and Gillian MacNaught and Paul Marsden and Matthews, {Julian C.}",

year = "2019",

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doi = "10.1109/NSS/MIC42101.2019.9059802",

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booktitle = "2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019",

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Krokos, G , MacKewn, J , Pike, L, Hallett, W, Markiewicz, P, Barnes, A, Rega, M, Fryer, TD, Manavaki, R, Anton-Rodriguez, JM, Howell, E, Wimberley, C, Clark, T, MacNaught, G, Marsden, P & Matthews, JC 2019, Qualification of the Seven Dementias Platform UK PET-MR Scanners for Multicentre Trials. in 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019., 9059802, 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019, Institute of Electrical and Electronics Engineers Inc., 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019, Manchester, United Kingdom, 26/10/2019. https://doi.org/10.1109/NSS/MIC42101.2019.9059802

Qualification of the Seven Dementias Platform UK PET-MR Scanners for Multicentre Trials. / Krokos, Georgios ; MacKewn, Jane ; Pike, Lucy et al.
2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. 9059802 (2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019).

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

TY - CHAP

T1 - Qualification of the Seven Dementias Platform UK PET-MR Scanners for Multicentre Trials

AU - Krokos, Georgios

AU - MacKewn, Jane

AU - Pike, Lucy

AU - Hallett, William

AU - Markiewicz, Pawel

AU - Barnes, Anna

AU - Rega, Marilena

AU - Fryer, Tim D.

AU - Manavaki, Roido

AU - Anton-Rodriguez, Jose M.

AU - Howell, Elizabeth

AU - Wimberley, Catriona

AU - Clark, Tim

AU - MacNaught, Gillian

AU - Marsden, Paul

AU - Matthews, Julian C.

PY - 2019/10

Y1 - 2019/10

N2 - Standardisation of PET scanners participating in multicentre trials is important in achieving reliable results and in maximizing the power of the study. The first multicentre clinical trial studies involving seven PET-MR scanners in the UK (four GE SIGNA and three Siemens mMR) are underway, led by Dementias Platform UK. In this study, the qualification of the seven scanners was tested using the NEMA image quality phantom. Consistent scanning methodology was followed across all sites with a 5:1 sphere-to-background contrast ratio and a CT-based μ-map used for attenuation correction. The reconstruction parameters were consistent between scanners of the same manufacturer. The SUVmean and SUVmax for all spheres were comparable between all scanners and within EARL performance specifications. Moreover, the averaged SUV values from all scanners were similar with the averaged corresponding values from 25 PET-CT scanners across the UK currently eligible to participate in multicentre trials. In conclusion, these preliminary results support the reliable comparison of PET performance across the PET-MR scanners.

AB - Standardisation of PET scanners participating in multicentre trials is important in achieving reliable results and in maximizing the power of the study. The first multicentre clinical trial studies involving seven PET-MR scanners in the UK (four GE SIGNA and three Siemens mMR) are underway, led by Dementias Platform UK. In this study, the qualification of the seven scanners was tested using the NEMA image quality phantom. Consistent scanning methodology was followed across all sites with a 5:1 sphere-to-background contrast ratio and a CT-based μ-map used for attenuation correction. The reconstruction parameters were consistent between scanners of the same manufacturer. The SUVmean and SUVmax for all spheres were comparable between all scanners and within EARL performance specifications. Moreover, the averaged SUV values from all scanners were similar with the averaged corresponding values from 25 PET-CT scanners across the UK currently eligible to participate in multicentre trials. In conclusion, these preliminary results support the reliable comparison of PET performance across the PET-MR scanners.

KW - Dementias Platform UK

KW - NEMA phantom

KW - PET-MR

KW - quality control

KW - standardization

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DO - 10.1109/NSS/MIC42101.2019.9059802

M3 - Conference paper

AN - SCOPUS:85083555770

T3 - 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019

BT - 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019

PB - Institute of Electrical and Electronics Engineers Inc.

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ER -

Krokos G , MacKewn J , Pike L, Hallett W, Markiewicz P, Barnes A et al. Qualification of the Seven Dementias Platform UK PET-MR Scanners for Multicentre Trials. In 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. 9059802. (2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019). doi: 10.1109/NSS/MIC42101.2019.9059802

Qualification of the Seven Dementias Platform UK PET-MR Scanners for Multicentre Trials

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Keywords

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