Quantitative Assessment of Perfusion: Where Are We Now?

Eva Sammut; Niloufar Zarinabad Nooralipour; Pier Filippo Vianello; Amedeo Chiribiri

doi:10.1007/s12410-014-9278-9

Quantitative Assessment of Perfusion: Where Are We Now?

Eva Sammut, Niloufar Zarinabad Nooralipour, Pier Filippo Vianello, Amedeo Chiribiri

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Abstract

The assessment of myocardial perfusion by cardiac magnetic resonance (CMR) is increasingly used for non-invasive diagnosis of myocardial ischaemia. Perfusion CMR has a number of competitive advantages over other cardiac imaging modalities, including the possibility to perform quantitative analysis of stress-induced myocardial blood flow and to quantify myocardial perfusion reserve. Several methods for quantitative analysis have been described and extensively validated in preclinical and clinical models of myocardial ischaemia. Nevertheless, quantitative perfusion CMR analysis has, thus far, been restricted to the research arena. Its use in clinical implementation has not yet been the subject of major clinical studies. This review aims to discuss the evidence supporting the use of quantitative perfusion analysis and to discuss the open issues preventing an effective translation to clinical practice.

Original language	English
Article number	9278
Number of pages	11
Journal	Current Cardiovascular Imaging Reports
Volume	7
Issue number	7
DOIs	https://doi.org/10.1007/s12410-014-9278-9
Publication status	E-pub ahead of print - Jul 2014

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title = "Quantitative Assessment of Perfusion: Where Are We Now?",

abstract = "The assessment of myocardial perfusion by cardiac magnetic resonance (CMR) is increasingly used for non-invasive diagnosis of myocardial ischaemia. Perfusion CMR has a number of competitive advantages over other cardiac imaging modalities, including the possibility to perform quantitative analysis of stress-induced myocardial blood flow and to quantify myocardial perfusion reserve. Several methods for quantitative analysis have been described and extensively validated in preclinical and clinical models of myocardial ischaemia. Nevertheless, quantitative perfusion CMR analysis has, thus far, been restricted to the research arena. Its use in clinical implementation has not yet been the subject of major clinical studies. This review aims to discuss the evidence supporting the use of quantitative perfusion analysis and to discuss the open issues preventing an effective translation to clinical practice.",

author = "Eva Sammut and {Zarinabad Nooralipour}, Niloufar and Vianello, {Pier Filippo} and Amedeo Chiribiri",

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AU - Sammut, Eva

AU - Zarinabad Nooralipour, Niloufar

AU - Vianello, Pier Filippo

AU - Chiribiri, Amedeo

PY - 2014/7

Y1 - 2014/7

N2 - The assessment of myocardial perfusion by cardiac magnetic resonance (CMR) is increasingly used for non-invasive diagnosis of myocardial ischaemia. Perfusion CMR has a number of competitive advantages over other cardiac imaging modalities, including the possibility to perform quantitative analysis of stress-induced myocardial blood flow and to quantify myocardial perfusion reserve. Several methods for quantitative analysis have been described and extensively validated in preclinical and clinical models of myocardial ischaemia. Nevertheless, quantitative perfusion CMR analysis has, thus far, been restricted to the research arena. Its use in clinical implementation has not yet been the subject of major clinical studies. This review aims to discuss the evidence supporting the use of quantitative perfusion analysis and to discuss the open issues preventing an effective translation to clinical practice.

AB - The assessment of myocardial perfusion by cardiac magnetic resonance (CMR) is increasingly used for non-invasive diagnosis of myocardial ischaemia. Perfusion CMR has a number of competitive advantages over other cardiac imaging modalities, including the possibility to perform quantitative analysis of stress-induced myocardial blood flow and to quantify myocardial perfusion reserve. Several methods for quantitative analysis have been described and extensively validated in preclinical and clinical models of myocardial ischaemia. Nevertheless, quantitative perfusion CMR analysis has, thus far, been restricted to the research arena. Its use in clinical implementation has not yet been the subject of major clinical studies. This review aims to discuss the evidence supporting the use of quantitative perfusion analysis and to discuss the open issues preventing an effective translation to clinical practice.

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JO - Current Cardiovascular Imaging Reports

JF - Current Cardiovascular Imaging Reports

IS - 7

M1 - 9278

ER -

Quantitative Assessment of Perfusion: Where Are We Now?

Abstract

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