Randomised weaning trial comparing assist control to pressure support ventilation

Deena Shefali-Patel; Vadivelam Murthy; Simon Hannam; Silke Lee; Gerrard F. Rafferty; Anne Greenough

doi:10.1136/archdischild-2011-300974

Randomised weaning trial comparing assist control to pressure support ventilation

Deena Shefali-Patel, Vadivelam Murthy, Simon Hannam, Silke Lee, Gerrard F. Rafferty, Anne Greenough

King's College London

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Objectives: To determine if the work of breathing was lower, respiratory muscle strength greater, but the degree of asynchrony higher during weaning by assist control ventilation (ACV) rather than pressure support ventilation (PSV) and if any differences were associated with a shorter duration of weaning.

Design: Randomised trial

Setting: Tertiary neonatal unit

Patients: Thirty-six infants, median gestational age 29 (range 24 to 39) weeks

Intervention: Weaning by either ACV or PSV.

Main outcome measures: At baseline, 24 hours after entering the study and immediately prior to extubation, the work of breathing (PTPdi), thoracoabdominal asynchrony (TAA) and respiratory muscle strength (Pimax) were assessed and weaning duration recorded.

Results: There were no significant differences in the median PTPdi, TAA and Pimax results at any time point. The inflation times during ACV and PSV were similar. The median duration of weaning was 34 (range 7-100) hours in the ACV group and 27 (range 10-169) hours in the PSV group (p=0.88).

Conclusion: No significant differences were found between weaning by PSV and ACV when similar inflation times were used.

Original language	English
Pages (from-to)	F429-F433
Number of pages	5
Journal	Archives of Disease in Childhood Fetal and Neonatal Edition
Volume	97
Issue number	6
DOIs	https://doi.org/10.1136/archdischild-2011-300974
Publication status	Published - Nov 2012

Keywords

Ventilator Weaning
Work of Breathing
Respiration
Humans
Treatment Outcome
Infant, Newborn
Respiration, Artificial
Positive-Pressure Respiration
Male
Female

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10.1136/archdischild-2011-300974

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title = "Randomised weaning trial comparing assist control to pressure support ventilation",

abstract = "Objectives: To determine if the work of breathing was lower, respiratory muscle strength greater, but the degree of asynchrony higher during weaning by assist control ventilation (ACV) rather than pressure support ventilation (PSV) and if any differences were associated with a shorter duration of weaning. Design: Randomised trial Setting: Tertiary neonatal unit Patients: Thirty-six infants, median gestational age 29 (range 24 to 39) weeks Intervention: Weaning by either ACV or PSV. Main outcome measures: At baseline, 24 hours after entering the study and immediately prior to extubation, the work of breathing (PTPdi), thoracoabdominal asynchrony (TAA) and respiratory muscle strength (Pimax) were assessed and weaning duration recorded. Results: There were no significant differences in the median PTPdi, TAA and Pimax results at any time point. The inflation times during ACV and PSV were similar. The median duration of weaning was 34 (range 7-100) hours in the ACV group and 27 (range 10-169) hours in the PSV group (p=0.88). Conclusion: No significant differences were found between weaning by PSV and ACV when similar inflation times were used.",

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author = "Deena Shefali-Patel and Vadivelam Murthy and Simon Hannam and Silke Lee and Rafferty, {Gerrard F.} and Anne Greenough",

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doi = "10.1136/archdischild-2011-300974",

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AU - Murthy, Vadivelam

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AU - Lee, Silke

AU - Rafferty, Gerrard F.

AU - Greenough, Anne

PY - 2012/11

Y1 - 2012/11

N2 - Objectives: To determine if the work of breathing was lower, respiratory muscle strength greater, but the degree of asynchrony higher during weaning by assist control ventilation (ACV) rather than pressure support ventilation (PSV) and if any differences were associated with a shorter duration of weaning. Design: Randomised trial Setting: Tertiary neonatal unit Patients: Thirty-six infants, median gestational age 29 (range 24 to 39) weeks Intervention: Weaning by either ACV or PSV. Main outcome measures: At baseline, 24 hours after entering the study and immediately prior to extubation, the work of breathing (PTPdi), thoracoabdominal asynchrony (TAA) and respiratory muscle strength (Pimax) were assessed and weaning duration recorded. Results: There were no significant differences in the median PTPdi, TAA and Pimax results at any time point. The inflation times during ACV and PSV were similar. The median duration of weaning was 34 (range 7-100) hours in the ACV group and 27 (range 10-169) hours in the PSV group (p=0.88). Conclusion: No significant differences were found between weaning by PSV and ACV when similar inflation times were used.

AB - Objectives: To determine if the work of breathing was lower, respiratory muscle strength greater, but the degree of asynchrony higher during weaning by assist control ventilation (ACV) rather than pressure support ventilation (PSV) and if any differences were associated with a shorter duration of weaning. Design: Randomised trial Setting: Tertiary neonatal unit Patients: Thirty-six infants, median gestational age 29 (range 24 to 39) weeks Intervention: Weaning by either ACV or PSV. Main outcome measures: At baseline, 24 hours after entering the study and immediately prior to extubation, the work of breathing (PTPdi), thoracoabdominal asynchrony (TAA) and respiratory muscle strength (Pimax) were assessed and weaning duration recorded. Results: There were no significant differences in the median PTPdi, TAA and Pimax results at any time point. The inflation times during ACV and PSV were similar. The median duration of weaning was 34 (range 7-100) hours in the ACV group and 27 (range 10-169) hours in the PSV group (p=0.88). Conclusion: No significant differences were found between weaning by PSV and ACV when similar inflation times were used.

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KW - Treatment Outcome

KW - Infant, Newborn

KW - Respiration, Artificial

KW - Positive-Pressure Respiration

KW - Male

KW - Female

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Randomised weaning trial comparing assist control to pressure support ventilation

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