TY - JOUR
T1 - Recent advances in the development of metal complexes as antibacterial agents with metal-specific modes of action
AU - Waters, Jessica E.
AU - Stevens-Cullinane, Lars
AU - Siebenmann, Lukas
AU - Hess, Jeannine
N1 - Funding Information:
This work is supported by the Francis Crick Institute , which receives its core funding from Cancer Research UK ( CC2215 ), the United Kingdom Medical Research Council ( CC2215 ) and the Wellcome Trust ( CC2215 ), and by King’s College London . L.S was financially supported by the King’s College London International Scholarship ( ST12644 ). Figure 2 is generated using PyMOL Molecular Graphic System, Version 1.2r3pre, Schrödinger, LLC. Figure 3 is generated using BioRender.com.
Funding Information:
This work is supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (CC2215), the United Kingdom Medical Research Council (CC2215) and the Wellcome Trust (CC2215), and by King's College London. L.S was financially supported by the King's College London International Scholarship (ST12644). Figure 2 is generated using PyMOL Molecular Graphic System, Version 1.2r3pre, Schrödinger, LLC. Figure 3 is generated using BioRender.com.
Publisher Copyright:
© 2023 The Author(s)
PY - 2023/10
Y1 - 2023/10
N2 - The mounting burden of antimicrobial resistance (AMR) is one of the most concerning threats to public health worldwide. With low economic incentives and a dwindling supply of new drugs in clinical pipelines, more innovative approaches to novel drug design and development are desperately required. Metal-based compounds are rapidly emerging as an alternative to organic drugs, as they have the ability to kill pathogens via metal-specific modes of action. We herein review recent advances in metal-based antibacterial agents, including metal complexes, metal ions and catalytic metallodrugs. The review concludes with a perspective on the rational design of metal-based antibiotics, and how we can exploit their unique properties to tackle AMR.
AB - The mounting burden of antimicrobial resistance (AMR) is one of the most concerning threats to public health worldwide. With low economic incentives and a dwindling supply of new drugs in clinical pipelines, more innovative approaches to novel drug design and development are desperately required. Metal-based compounds are rapidly emerging as an alternative to organic drugs, as they have the ability to kill pathogens via metal-specific modes of action. We herein review recent advances in metal-based antibacterial agents, including metal complexes, metal ions and catalytic metallodrugs. The review concludes with a perspective on the rational design of metal-based antibiotics, and how we can exploit their unique properties to tackle AMR.
UR - http://www.scopus.com/inward/record.url?scp=85165242439&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2023.102347
DO - 10.1016/j.mib.2023.102347
M3 - Review article
C2 - 37467616
AN - SCOPUS:85165242439
SN - 1369-5274
VL - 75
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
M1 - 102347
ER -
