TY - JOUR
T1 - Recent progress in nanotechnology-based drug carriers for celastrol delivery
AU - Guo, Ling
AU - Zhang, Yongping
AU - Al-Jamal, Khuloud T.
N1 - Funding Information:
This work was financially supported by the Pharmaceutical Experimental Teaching Center Platform Construction Project (Guizhou Higher Education Development [2017] No. 158), the Guizhou Province High-level Innovative Talent Cultivation “Hundred Levels” Project ([2015]4030), and the National Natural Science Foundation of China (81960650).
Publisher Copyright:
© The Royal Society of Chemistry.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/10/7
Y1 - 2021/10/7
N2 - Celastrol (CLT) is an active ingredient that was initially discovered and extracted from the root of Tripterygium wilfordii. The potential pharmacological activities of CLT in cancer, obesity, and inflammatory, auto-immune, and neurodegenerative diseases have been demonstrated in recent years. However, CLT's clinical application is extremely restricted by its low solubility/permeability, poor bioavailability, and potential off-target toxicity. The advent of nanotechnology provides a solution to improve the oral bioavailability, therapeutic effects or tissue-targeting ability of CLT. This review focuses on the most recent advances, improvements, inventions, and updated literature of various nanocarrier systems for CLT.
AB - Celastrol (CLT) is an active ingredient that was initially discovered and extracted from the root of Tripterygium wilfordii. The potential pharmacological activities of CLT in cancer, obesity, and inflammatory, auto-immune, and neurodegenerative diseases have been demonstrated in recent years. However, CLT's clinical application is extremely restricted by its low solubility/permeability, poor bioavailability, and potential off-target toxicity. The advent of nanotechnology provides a solution to improve the oral bioavailability, therapeutic effects or tissue-targeting ability of CLT. This review focuses on the most recent advances, improvements, inventions, and updated literature of various nanocarrier systems for CLT.
UR - http://www.scopus.com/inward/record.url?scp=85116496593&partnerID=8YFLogxK
U2 - 10.1039/d1bm00639h
DO - 10.1039/d1bm00639h
M3 - Article
AN - SCOPUS:85116496593
SN - 2047-4830
VL - 9
SP - 6355
EP - 6380
JO - Biomaterials Science
JF - Biomaterials Science
IS - 19
ER -
