Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis

S Tognin; A Riecher-Rössler; E M Meisenzahl; S J Wood; C Hutton; S J Borgwardt; N Koutsouleris; A R Yung; P Allen; L J Phillips; P D McGorry; I Valli; D Velakoulis; B Nelson; J Woolley; C Pantelis; P McGuire; A Mechelli

doi:10.1017/S0033291713000998

Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis

S Tognin, A Riecher-Rössler, E M Meisenzahl, S J Wood, C Hutton, S J Borgwardt, N Koutsouleris, A R Yung, P Allen, L J Phillips, P D McGorry, I Valli, D Velakoulis, B Nelson, J Woolley, C Pantelis, P McGuire, A Mechelli

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Abstract

BACKGROUND: Grey matter volume and cortical thickness represent two complementary aspects of brain structure. Several studies have described reductions in grey matter volume in people at ultra-high risk (UHR) of psychosis; however, little is known about cortical thickness in this group. The aim of the present study was to investigate cortical thickness alterations in UHR subjects and compare individuals who subsequently did and did not develop psychosis. Method We examined magnetic resonance imaging data collected at four different scanning sites. The UHR subjects were followed up for at least 2 years. Subsequent to scanning, 50 UHR subjects developed psychosis and 117 did not. Cortical thickness was examined in regions previously identified as sites of neuroanatomical alterations in UHR subjects, using voxel-based cortical thickness. RESULTS: At baseline UHR subjects, compared with controls, showed reduced cortical thickness in the right parahippocampal gyrus (p

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Psychological Medicine
DOIs	https://doi.org/10.1017/S0033291713000998
Publication status	E-pub ahead of print - 10 May 2013

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Tognin, S., Riecher-Rössler, A., Meisenzahl, E. M., Wood, S. J., Hutton, C., Borgwardt, S. J., Koutsouleris, N., Yung, A. R., Allen, P., Phillips, L. J., McGorry, P. D., Valli, I., Velakoulis, D., Nelson, B., Woolley, J., Pantelis, C., McGuire, P., & Mechelli, A. (2013). Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis. Psychological Medicine, 1-10. Advance online publication. https://doi.org/10.1017/S0033291713000998

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title = "Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis",

abstract = "BACKGROUND: Grey matter volume and cortical thickness represent two complementary aspects of brain structure. Several studies have described reductions in grey matter volume in people at ultra-high risk (UHR) of psychosis; however, little is known about cortical thickness in this group. The aim of the present study was to investigate cortical thickness alterations in UHR subjects and compare individuals who subsequently did and did not develop psychosis. Method We examined magnetic resonance imaging data collected at four different scanning sites. The UHR subjects were followed up for at least 2 years. Subsequent to scanning, 50 UHR subjects developed psychosis and 117 did not. Cortical thickness was examined in regions previously identified as sites of neuroanatomical alterations in UHR subjects, using voxel-based cortical thickness. RESULTS: At baseline UHR subjects, compared with controls, showed reduced cortical thickness in the right parahippocampal gyrus (p ",

author = "S Tognin and A Riecher-R{\"o}ssler and Meisenzahl, {E M} and Wood, {S J} and C Hutton and Borgwardt, {S J} and N Koutsouleris and Yung, {A R} and P Allen and Phillips, {L J} and McGorry, {P D} and I Valli and D Velakoulis and B Nelson and J Woolley and C Pantelis and P McGuire and A Mechelli",

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doi = "10.1017/S0033291713000998",

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journal = "Psychological Medicine",

issn = "1469-8978",

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Tognin, S, Riecher-Rössler, A, Meisenzahl, EM, Wood, SJ, Hutton, C, Borgwardt, SJ, Koutsouleris, N, Yung, AR, Allen, P, Phillips, LJ, McGorry, PD, Valli, I, Velakoulis, D, Nelson, B, Woolley, J, Pantelis, C, McGuire, P & Mechelli, A 2013, 'Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis', Psychological Medicine, pp. 1-10. https://doi.org/10.1017/S0033291713000998

TY - JOUR

T1 - Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis

AU - Tognin, S

AU - Riecher-Rössler, A

AU - Meisenzahl, E M

AU - Wood, S J

AU - Hutton, C

AU - Borgwardt, S J

AU - Koutsouleris, N

AU - Yung, A R

AU - Allen, P

AU - Phillips, L J

AU - McGorry, P D

AU - Valli, I

AU - Velakoulis, D

AU - Nelson, B

AU - Woolley, J

AU - Pantelis, C

AU - McGuire, P

AU - Mechelli, A

PY - 2013/5/10

Y1 - 2013/5/10

N2 - BACKGROUND: Grey matter volume and cortical thickness represent two complementary aspects of brain structure. Several studies have described reductions in grey matter volume in people at ultra-high risk (UHR) of psychosis; however, little is known about cortical thickness in this group. The aim of the present study was to investigate cortical thickness alterations in UHR subjects and compare individuals who subsequently did and did not develop psychosis. Method We examined magnetic resonance imaging data collected at four different scanning sites. The UHR subjects were followed up for at least 2 years. Subsequent to scanning, 50 UHR subjects developed psychosis and 117 did not. Cortical thickness was examined in regions previously identified as sites of neuroanatomical alterations in UHR subjects, using voxel-based cortical thickness. RESULTS: At baseline UHR subjects, compared with controls, showed reduced cortical thickness in the right parahippocampal gyrus (p

AB - BACKGROUND: Grey matter volume and cortical thickness represent two complementary aspects of brain structure. Several studies have described reductions in grey matter volume in people at ultra-high risk (UHR) of psychosis; however, little is known about cortical thickness in this group. The aim of the present study was to investigate cortical thickness alterations in UHR subjects and compare individuals who subsequently did and did not develop psychosis. Method We examined magnetic resonance imaging data collected at four different scanning sites. The UHR subjects were followed up for at least 2 years. Subsequent to scanning, 50 UHR subjects developed psychosis and 117 did not. Cortical thickness was examined in regions previously identified as sites of neuroanatomical alterations in UHR subjects, using voxel-based cortical thickness. RESULTS: At baseline UHR subjects, compared with controls, showed reduced cortical thickness in the right parahippocampal gyrus (p

U2 - 10.1017/S0033291713000998

DO - 10.1017/S0033291713000998

M3 - Article

C2 - 23659473

SN - 1469-8978

SP - 1

EP - 10

JO - Psychological Medicine

JF - Psychological Medicine

ER -

Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis

Abstract

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