Regional Pulmonary Blood Flow: Comparison of Dynamic Contrast-Enhanced MR Perfusion and Phase-Contrast MR

Regional pulmonary blood flow can be assessed using both dynamic contrast-enhanced (DCE) MR and phase-contrast (PC) MR. These methods provide somewhat complementary information: DCE MR can assess flow over the entire lung while PC MR can detect rapid changes in flow to a targeted region. Although both methods are considered accurate, one may be more feasible than the other depending on pathology, patient condition, and availability of an intravenous route. The objective of this study was to establish a consensus between the two methods by comparing paired DCE MR and PC MR measurements of relative blood flow in Yorkshire piglets (N = 5, age = 7 days, weight = 3.3 +/- 0.6 kg) under various physiological states including regional lung collapse. A strong correlation (R(2) = 0.71, P <0.01) was observed between the methods. In conclusion, DCE MR and PC MR provide a consistent measure of changes in regional pulmonary blood flow. Magn Reson Med 61:1249-1254, 2009. (C) 2009 Wiley-Liss, Inc.