Regulation of GPCR-mediated smooth muscle contraction: Implications for asthma and pulmonary hypertension

D. B. Wright; S. Tripathi; A. Sikarwar; K. T. Santosh; J. Perez-Zoghbi; O. O. Ojo; N. Irechukwu; J. P. T. Ward; D. Schaafsma

doi:10.1016/j.pupt.2012.06.005

Regulation of GPCR-mediated smooth muscle contraction: Implications for asthma and pulmonary hypertension

D. B. Wright, S. Tripathi, A. Sikarwar, K. T. Santosh, J. Perez-Zoghbi, O. O. Ojo, N. Irechukwu, J. P. T. Ward, D. Schaafsma^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Contractile G-protein-coupled receptors (GPCRs) have emerged as key regulators of smooth muscle contraction, both under healthy and diseased conditions. This brief review will discuss some key topics and novel insights regarding GPCR-mediated airway and vascular smooth muscle contraction as discussed at the 7th International Young Investigators' Symposium on Smooth Muscle (2011, Winnipeg, Manitoba, Canada) and will in particular focus on processes driving Ca2+-mobilization and -sensitization. (C) 2012 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	121-131
Number of pages	11
Journal	PULMONARY PHARMACOLOGY AND THERAPEUTICS
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.pupt.2012.06.005
Publication status	Published - Feb 2013

Keywords

Calcium
Ca2+-mobilization
Ca2+-sensitization
CPI-17
Palmitoylation
ROCK
PROTEIN-KINASE-C
MYOSIN LIGHT-CHAIN
BETA-GAMMA-SUBUNITS
AIRWAY HYPERRESPONSIVE RATS
ENDOTHELIN-INDUCED CONTRACTION
OPERATED CALCIUM-CHANNEL
NITRIC-OXIDE SYNTHASE
TRIMERIC G-PROTEINS
CA2+ SENSITIZATION
RHO-KINASE

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title = "Regulation of GPCR-mediated smooth muscle contraction: Implications for asthma and pulmonary hypertension",

abstract = "Contractile G-protein-coupled receptors (GPCRs) have emerged as key regulators of smooth muscle contraction, both under healthy and diseased conditions. This brief review will discuss some key topics and novel insights regarding GPCR-mediated airway and vascular smooth muscle contraction as discussed at the 7th International Young Investigators' Symposium on Smooth Muscle (2011, Winnipeg, Manitoba, Canada) and will in particular focus on processes driving Ca2+-mobilization and -sensitization. (C) 2012 Elsevier Ltd. All rights reserved.",

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author = "Wright, {D. B.} and S. Tripathi and A. Sikarwar and Santosh, {K. T.} and J. Perez-Zoghbi and Ojo, {O. O.} and N. Irechukwu and Ward, {J. P. T.} and D. Schaafsma",

year = "2013",

month = feb,

doi = "10.1016/j.pupt.2012.06.005",

language = "English",

volume = "26",

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T1 - Regulation of GPCR-mediated smooth muscle contraction: Implications for asthma and pulmonary hypertension

AU - Wright, D. B.

AU - Tripathi, S.

AU - Sikarwar, A.

AU - Santosh, K. T.

AU - Perez-Zoghbi, J.

AU - Ojo, O. O.

AU - Irechukwu, N.

AU - Ward, J. P. T.

AU - Schaafsma, D.

PY - 2013/2

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N2 - Contractile G-protein-coupled receptors (GPCRs) have emerged as key regulators of smooth muscle contraction, both under healthy and diseased conditions. This brief review will discuss some key topics and novel insights regarding GPCR-mediated airway and vascular smooth muscle contraction as discussed at the 7th International Young Investigators' Symposium on Smooth Muscle (2011, Winnipeg, Manitoba, Canada) and will in particular focus on processes driving Ca2+-mobilization and -sensitization. (C) 2012 Elsevier Ltd. All rights reserved.

AB - Contractile G-protein-coupled receptors (GPCRs) have emerged as key regulators of smooth muscle contraction, both under healthy and diseased conditions. This brief review will discuss some key topics and novel insights regarding GPCR-mediated airway and vascular smooth muscle contraction as discussed at the 7th International Young Investigators' Symposium on Smooth Muscle (2011, Winnipeg, Manitoba, Canada) and will in particular focus on processes driving Ca2+-mobilization and -sensitization. (C) 2012 Elsevier Ltd. All rights reserved.

KW - Calcium

KW - Ca2+-mobilization

KW - Ca2+-sensitization

KW - CPI-17

KW - Palmitoylation

KW - ROCK

KW - PROTEIN-KINASE-C

KW - MYOSIN LIGHT-CHAIN

KW - BETA-GAMMA-SUBUNITS

KW - AIRWAY HYPERRESPONSIVE RATS

KW - ENDOTHELIN-INDUCED CONTRACTION

KW - OPERATED CALCIUM-CHANNEL

KW - NITRIC-OXIDE SYNTHASE

KW - TRIMERIC G-PROTEINS

KW - CA2+ SENSITIZATION

KW - RHO-KINASE

U2 - 10.1016/j.pupt.2012.06.005

DO - 10.1016/j.pupt.2012.06.005

M3 - Article

SN - 1094-5539

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SP - 121

EP - 131

JO - PULMONARY PHARMACOLOGY AND THERAPEUTICS

JF - PULMONARY PHARMACOLOGY AND THERAPEUTICS

IS - 1

ER -

Regulation of GPCR-mediated smooth muscle contraction: Implications for asthma and pulmonary hypertension

Abstract

Keywords

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