Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population

Marcella Montagnese; Franziska Knolle; Joost Haarsma; Juliet D. Griffin; Alex Richards; Petra E. Vertes; Beatrix Kiddle; Paul C. Fletcher; Peter B. Jones; Michael J. Owen; Peter Fonagy; Edward T. Bullmore; Raymond J. Dolan; Michael Moutoussis; Ian M. Goodyer; Graham K. Murray

doi:10.1016/j.schres.2020.04.022

Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population

Marcella Montagnese, Franziska Knolle, Joost Haarsma, Juliet D. Griffin, Alex Richards, Petra E. Vertes, Beatrix Kiddle, Paul C. Fletcher, Peter B. Jones, Michael J. Owen, Peter Fonagy, Edward T. Bullmore, Raymond J. Dolan, Michael Moutoussis, Ian M. Goodyer, Graham K. Murray

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Original language	English
Pages (from-to)	389-396
Journal	Schizophrenia Research
Volume	222
DOIs	https://doi.org/10.1016/j.schres.2020.04.022
Publication status	Published - Aug 2020

Keywords

Psychosis
Schizophrenia
PRS
Bayesian
Reinforcement learning
Go/NoGo task
Computational psychiatry

Access to Document

10.1016/j.schres.2020.04.022

Cite this

Montagnese, M., Knolle, F., Haarsma, J., Griffin, J. D., Richards, A., Vertes, P. E., Kiddle, B., Fletcher, P. C., Jones, P. B., Owen, M. J., Fonagy, P., Bullmore, E. T., Dolan, R. J., Moutoussis, M., Goodyer, I. M., & Murray, G. K. (2020). Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population. Schizophrenia Research, 222, 389-396. https://doi.org/10.1016/j.schres.2020.04.022

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title = "Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population",

keywords = "Psychosis, Schizophrenia, PRS, Bayesian, Reinforcement learning, Go/NoGo task, Computational psychiatry",

author = "Marcella Montagnese and Franziska Knolle and Joost Haarsma and Griffin, {Juliet D.} and Alex Richards and Vertes, {Petra E.} and Beatrix Kiddle and Fletcher, {Paul C.} and Jones, {Peter B.} and Owen, {Michael J.} and Peter Fonagy and Bullmore, {Edward T.} and Dolan, {Raymond J.} and Michael Moutoussis and Goodyer, {Ian M.} and Murray, {Graham K.}",

year = "2020",

month = aug,

doi = "10.1016/j.schres.2020.04.022",

language = "English",

volume = "222",

pages = "389--396",

journal = "Schizophrenia Research",

issn = "0920-9964",

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Montagnese, M, Knolle, F, Haarsma, J, Griffin, JD, Richards, A, Vertes, PE, Kiddle, B, Fletcher, PC, Jones, PB, Owen, MJ, Fonagy, P, Bullmore, ET, Dolan, RJ, Moutoussis, M, Goodyer, IM & Murray, GK 2020, 'Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population', Schizophrenia Research, vol. 222, pp. 389-396. https://doi.org/10.1016/j.schres.2020.04.022

Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population. / Montagnese, Marcella; Knolle, Franziska; Haarsma, Joost et al.
In: Schizophrenia Research, Vol. 222, 08.2020, p. 389-396.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population

AU - Montagnese, Marcella

AU - Knolle, Franziska

AU - Haarsma, Joost

AU - Griffin, Juliet D.

AU - Richards, Alex

AU - Vertes, Petra E.

AU - Kiddle, Beatrix

AU - Fletcher, Paul C.

AU - Jones, Peter B.

AU - Owen, Michael J.

AU - Fonagy, Peter

AU - Bullmore, Edward T.

AU - Dolan, Raymond J.

AU - Moutoussis, Michael

AU - Goodyer, Ian M.

AU - Murray, Graham K.

PY - 2020/8

Y1 - 2020/8

KW - Psychosis

KW - Schizophrenia

KW - PRS

KW - Bayesian

KW - Reinforcement learning

KW - Go/NoGo task

KW - Computational psychiatry

U2 - 10.1016/j.schres.2020.04.022

DO - 10.1016/j.schres.2020.04.022

M3 - Article

SN - 0920-9964

VL - 222

SP - 389

EP - 396

JO - Schizophrenia Research

JF - Schizophrenia Research

ER -