Reprogramming toward Heart Regeneration: Stem Cells and Beyond

Aitor Aguirre; Ignacio Sancho-Martinez; Juan Carlos Izpisua Belmonte

doi:10.1016/j.stem.2013.02.008

Reprogramming toward Heart Regeneration: Stem Cells and Beyond

Aitor Aguirre, Ignacio Sancho-Martinez, Juan Carlos Izpisua Belmonte

Centre for Stem Cells & Regenerative Medicine

Research output: Contribution to journal › Literature review › peer-review

57 Citations (Scopus)

Abstract

Finding a cure for cardiovascular disease remains a major unmet medical need. Recent investigations have started to unveil the mechanisms of mammalian heart regeneration. The study of the regenerative mechanisms in lower vertebrate and mammalian animal models has provided clues for the experimental activation of proregenerative responses in the heart. In parallel, the use of endogenous adult stem cell populations alongside the recent application of reprogramming technologies has created major expectations for the development of therapies targeting heart disease. Together, these new approaches are bringing us closer to more successful strategies for the treatment of heart disease.

Original language	English
Pages (from-to)	275-284
Number of pages	10
Journal	Cell Stem Cell
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/j.stem.2013.02.008
Publication status	Published - 7 Mar 2013

Keywords

Animals
Heart
Heart Diseases
Regeneration
Stem Cell Transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.stem.2013.02.008

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title = "Reprogramming toward Heart Regeneration: Stem Cells and Beyond",

abstract = "Finding a cure for cardiovascular disease remains a major unmet medical need. Recent investigations have started to unveil the mechanisms of mammalian heart regeneration. The study of the regenerative mechanisms in lower vertebrate and mammalian animal models has provided clues for the experimental activation of proregenerative responses in the heart. In parallel, the use of endogenous adult stem cell populations alongside the recent application of reprogramming technologies has created major expectations for the development of therapies targeting heart disease. Together, these new approaches are bringing us closer to more successful strategies for the treatment of heart disease.",

keywords = "Animals, Heart, Heart Diseases, Regeneration, Stem Cell Transplantation",

author = "Aitor Aguirre and Ignacio Sancho-Martinez and {Izpisua Belmonte}, {Juan Carlos}",

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AU - Izpisua Belmonte, Juan Carlos

PY - 2013/3/7

Y1 - 2013/3/7

N2 - Finding a cure for cardiovascular disease remains a major unmet medical need. Recent investigations have started to unveil the mechanisms of mammalian heart regeneration. The study of the regenerative mechanisms in lower vertebrate and mammalian animal models has provided clues for the experimental activation of proregenerative responses in the heart. In parallel, the use of endogenous adult stem cell populations alongside the recent application of reprogramming technologies has created major expectations for the development of therapies targeting heart disease. Together, these new approaches are bringing us closer to more successful strategies for the treatment of heart disease.

AB - Finding a cure for cardiovascular disease remains a major unmet medical need. Recent investigations have started to unveil the mechanisms of mammalian heart regeneration. The study of the regenerative mechanisms in lower vertebrate and mammalian animal models has provided clues for the experimental activation of proregenerative responses in the heart. In parallel, the use of endogenous adult stem cell populations alongside the recent application of reprogramming technologies has created major expectations for the development of therapies targeting heart disease. Together, these new approaches are bringing us closer to more successful strategies for the treatment of heart disease.

KW - Animals

KW - Heart

KW - Heart Diseases

KW - Regeneration

KW - Stem Cell Transplantation

U2 - 10.1016/j.stem.2013.02.008

DO - 10.1016/j.stem.2013.02.008

M3 - Literature review

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JF - Cell Stem Cell

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ER -

Reprogramming toward Heart Regeneration: Stem Cells and Beyond

Abstract

Keywords

UN SDGs

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