TY - JOUR
T1 - Resistance amongst yeasts isolated from the oral cavities of patients with advanced cancer
AU - Davies, A
AU - Brailsford, S
AU - Broadley, K
AU - Beighton, D
PY - 2002
Y1 - 2002
N2 - The aim of this study was to determine the prevalence of in vitro resistance amongst yeasts isolated from the oral cavities of patients with advanced cancer. The National Committee for Clinical Laboratory Standards' broth microdilution method was used to determine the sensitivities to fluconazole, itraconazole, ketoconazole, and nystatin, whilst the Etest(R) method was used to determine the sensitivity to amphotericin B. The prevalence of in vitroresistance was: amphotericin B, 2%; fluconazole, 8% itraconazole, 22%; ketoconazole, 7%; nystatin, 0%. Moreover, 28% of the yeasts was resistant to one or more of the azole group of anti-fungal drugs. The results of this study suggest that azole resistance may become a clinical problem in palliative care.
AB - The aim of this study was to determine the prevalence of in vitro resistance amongst yeasts isolated from the oral cavities of patients with advanced cancer. The National Committee for Clinical Laboratory Standards' broth microdilution method was used to determine the sensitivities to fluconazole, itraconazole, ketoconazole, and nystatin, whilst the Etest(R) method was used to determine the sensitivity to amphotericin B. The prevalence of in vitroresistance was: amphotericin B, 2%; fluconazole, 8% itraconazole, 22%; ketoconazole, 7%; nystatin, 0%. Moreover, 28% of the yeasts was resistant to one or more of the azole group of anti-fungal drugs. The results of this study suggest that azole resistance may become a clinical problem in palliative care.
UR - http://www.scopus.com/inward/record.url?scp=0036025365&partnerID=8YFLogxK
U2 - 10.1191/0269216302pm583oa
DO - 10.1191/0269216302pm583oa
M3 - Article
VL - 16
SP - 527
EP - 531
JO - Palliative Medicine
JF - Palliative Medicine
IS - 6
ER -
