Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes-proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS

A. Porwit; A. A. van de Loosdrecht; P. Bettelheim; L. Eidenschink Brodersen; K. Burbury; E. Cremers; M. G. Della Porta; Robin Ireland; U. Johansson; S. Matarraz; K. Ogata; A. Orfao; F. Preijers; K. Psarra; D. Subira; P. Valent; V. H. J. van der Velden; D. Wells; T. M. Westers; W. Kern; M. C. Bene; IMDSFlow

doi:10.1038/leu.2014.191

Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes-proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS

A. Porwit, A. A. van de Loosdrecht, P. Bettelheim, L. Eidenschink Brodersen, K. Burbury, E. Cremers, M. G. Della Porta, Robin Ireland, U. Johansson, S. Matarraz, K. Ogata, A. Orfao, F. Preijers, K. Psarra, D. Subira, P. Valent, V. H. J. van der Velden, D. Wells, T. M. Westers, W. KernM. C. Bene^*, IMDSFlow

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

120 Citations (Scopus)

Abstract

Definite progress has been made in the exploration of myelodysplastic syndromes (MDS) by flow cytometry (FCM) since the publication of the World Health Organization 2008 classification of myeloid neoplasms. An international working party initiated within the European LeukemiaNet and extended to include members from Australia, Canada, Japan, Taiwan and the United States has, through several workshops, developed and subsequently published consensus recommendations. The latter deal with preanalytical precautions, and propose small and large panels, which allow evaluating immunophenotypic anomalies and calculating myelodysplasia scores. The current paper provides guidelines that strongly recommend the integration of FCM data with other diagnostic tools in the diagnostic work-up of MDS.

Original language	English
Pages (from-to)	1793-1798
Number of pages	6
Journal	Leukemia
Volume	28
Issue number	9
DOIs	https://doi.org/10.1038/leu.2014.191
Publication status	Published - Sept 2014

Keywords

PROGNOSTIC SCORING SYSTEM
EUROPEAN LEUKEMIANET
BONE-MARROW
LOW-GRADE
DIAGNOSTIC APPLICATION
MULTICENTER VALIDATION
ERYTHROID DYSPLASIA
ANTIGEN-EXPRESSION
BLAST CELLS
UTILITY

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Porwit, A., van de Loosdrecht, A. A., Bettelheim, P., Brodersen, L. E., Burbury, K., Cremers, E., Della Porta, M. G., Ireland, R., Johansson, U., Matarraz, S., Ogata, K., Orfao, A., Preijers, F., Psarra, K., Subira, D., Valent, P., van der Velden, V. H. J., Wells, D., Westers, T. M., ... IMDSFlow (2014). Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes-proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS. Leukemia, 28(9), 1793-1798. https://doi.org/10.1038/leu.2014.191

@article{92bd5503fa5042848cc81f031e55ddae,

title = "Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes-proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS",

abstract = "Definite progress has been made in the exploration of myelodysplastic syndromes (MDS) by flow cytometry (FCM) since the publication of the World Health Organization 2008 classification of myeloid neoplasms. An international working party initiated within the European LeukemiaNet and extended to include members from Australia, Canada, Japan, Taiwan and the United States has, through several workshops, developed and subsequently published consensus recommendations. The latter deal with preanalytical precautions, and propose small and large panels, which allow evaluating immunophenotypic anomalies and calculating myelodysplasia scores. The current paper provides guidelines that strongly recommend the integration of FCM data with other diagnostic tools in the diagnostic work-up of MDS.",

keywords = "PROGNOSTIC SCORING SYSTEM, EUROPEAN LEUKEMIANET, BONE-MARROW, LOW-GRADE, DIAGNOSTIC APPLICATION, MULTICENTER VALIDATION, ERYTHROID DYSPLASIA, ANTIGEN-EXPRESSION, BLAST CELLS, UTILITY",

author = "A. Porwit and {van de Loosdrecht}, {A. A.} and P. Bettelheim and Brodersen, {L. Eidenschink} and K. Burbury and E. Cremers and {Della Porta}, {M. G.} and Robin Ireland and U. Johansson and S. Matarraz and K. Ogata and A. Orfao and F. Preijers and K. Psarra and D. Subira and P. Valent and {van der Velden}, {V. H. J.} and D. Wells and Westers, {T. M.} and W. Kern and Bene, {M. C.} and IMDSFlow",

year = "2014",

month = sep,

doi = "10.1038/leu.2014.191",

language = "English",

volume = "28",

pages = "1793--1798",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Springer Nature [academic journals on nature.com]",

number = "9",

}

Porwit, A, van de Loosdrecht, AA, Bettelheim, P, Brodersen, LE, Burbury, K, Cremers, E, Della Porta, MG, Ireland, R, Johansson, U, Matarraz, S, Ogata, K, Orfao, A, Preijers, F, Psarra, K, Subira, D, Valent, P, van der Velden, VHJ, Wells, D, Westers, TM, Kern, W, Bene, MC & IMDSFlow 2014, 'Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes-proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS', Leukemia, vol. 28, no. 9, pp. 1793-1798. https://doi.org/10.1038/leu.2014.191

Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes-proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS. / Porwit, A.; van de Loosdrecht, A. A.; Bettelheim, P. et al.
In: Leukemia, Vol. 28, No. 9, 09.2014, p. 1793-1798.

Research output: Contribution to journal › Literature review › peer-review

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AU - Porwit, A.

AU - van de Loosdrecht, A. A.

AU - Bettelheim, P.

AU - Brodersen, L. Eidenschink

AU - Burbury, K.

AU - Cremers, E.

AU - Della Porta, M. G.

AU - Ireland, Robin

AU - Johansson, U.

AU - Matarraz, S.

AU - Ogata, K.

AU - Orfao, A.

AU - Preijers, F.

AU - Psarra, K.

AU - Subira, D.

AU - Valent, P.

AU - van der Velden, V. H. J.

AU - Wells, D.

AU - Westers, T. M.

AU - Kern, W.

AU - Bene, M. C.

AU - IMDSFlow

PY - 2014/9

Y1 - 2014/9

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AB - Definite progress has been made in the exploration of myelodysplastic syndromes (MDS) by flow cytometry (FCM) since the publication of the World Health Organization 2008 classification of myeloid neoplasms. An international working party initiated within the European LeukemiaNet and extended to include members from Australia, Canada, Japan, Taiwan and the United States has, through several workshops, developed and subsequently published consensus recommendations. The latter deal with preanalytical precautions, and propose small and large panels, which allow evaluating immunophenotypic anomalies and calculating myelodysplasia scores. The current paper provides guidelines that strongly recommend the integration of FCM data with other diagnostic tools in the diagnostic work-up of MDS.

KW - PROGNOSTIC SCORING SYSTEM

KW - EUROPEAN LEUKEMIANET

KW - BONE-MARROW

KW - LOW-GRADE

KW - DIAGNOSTIC APPLICATION

KW - MULTICENTER VALIDATION

KW - ERYTHROID DYSPLASIA

KW - ANTIGEN-EXPRESSION

KW - BLAST CELLS

KW - UTILITY

U2 - 10.1038/leu.2014.191

DO - 10.1038/leu.2014.191

M3 - Literature review

SN - 0887-6924

VL - 28

SP - 1793

EP - 1798

JO - Leukemia

JF - Leukemia

IS - 9

ER -