Rheumatoid arthritis association at 6q23

W Thomson; A Barton; X Ke; S Eyre; A Hinks; J Bowes; R Donn; D Symmons; S Hider; I N Bruce; A G Wilson; I Marinou; A Morgan; P Emery; A Carter; S Steer; L Hocking; D M Reid; P Wordsworth; P Harrison; D Strachan; J Worthington

doi:10.1038/ng.2007.32

Rheumatoid arthritis association at 6q23

W Thomson, A Barton, X Ke, S Eyre, A Hinks, J Bowes, R Donn, D Symmons, S Hider, I N Bruce, A G Wilson, I Marinou, A Morgan, P Emery, A Carter, S Steer, L Hocking, D M Reid, P Wordsworth, P HarrisonD Strachan, J Worthington

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Abstract

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5)-5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated ( trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 ( TNFAIP3)

Original language	English
Pages (from-to)	1431 - 1433
Number of pages	3
Journal	Nature Genetics
Volume	39
Issue number	12
DOIs	https://doi.org/10.1038/ng.2007.32
Publication status	Published - Dec 2007

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Thomson, W., Barton, A., Ke, X., Eyre, S., Hinks, A., Bowes, J., Donn, R., Symmons, D., Hider, S., Bruce, I. N., Wilson, A. G., Marinou, I., Morgan, A., Emery, P., Carter, A., Steer, S., Hocking, L., Reid, D. M., Wordsworth, P., ... Worthington, J. (2007). Rheumatoid arthritis association at 6q23. Nature Genetics, 39(12), 1431 - 1433. https://doi.org/10.1038/ng.2007.32

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abstract = "The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5)-5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated ( trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 ( TNFAIP3)",

author = "W Thomson and A Barton and X Ke and S Eyre and A Hinks and J Bowes and R Donn and D Symmons and S Hider and Bruce, {I N} and Wilson, {A G} and I Marinou and A Morgan and P Emery and A Carter and S Steer and L Hocking and Reid, {D M} and P Wordsworth and P Harrison and D Strachan and J Worthington",

year = "2007",

month = dec,

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language = "English",

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Thomson, W, Barton, A, Ke, X, Eyre, S, Hinks, A, Bowes, J, Donn, R, Symmons, D, Hider, S, Bruce, IN, Wilson, AG, Marinou, I, Morgan, A, Emery, P, Carter, A, Steer, S, Hocking, L, Reid, DM, Wordsworth, P, Harrison, P, Strachan, D & Worthington, J 2007, 'Rheumatoid arthritis association at 6q23', Nature Genetics, vol. 39, no. 12, pp. 1431 - 1433. https://doi.org/10.1038/ng.2007.32

TY - JOUR

T1 - Rheumatoid arthritis association at 6q23

AU - Thomson, W

AU - Barton, A

AU - Ke, X

AU - Eyre, S

AU - Hinks, A

AU - Bowes, J

AU - Donn, R

AU - Symmons, D

AU - Hider, S

AU - Bruce, I N

AU - Wilson, A G

AU - Marinou, I

AU - Morgan, A

AU - Emery, P

AU - Carter, A

AU - Steer, S

AU - Hocking, L

AU - Reid, D M

AU - Wordsworth, P

AU - Harrison, P

AU - Strachan, D

AU - Worthington, J

PY - 2007/12

Y1 - 2007/12

N2 - The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5)-5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated ( trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 ( TNFAIP3)

AB - The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5)-5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated ( trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 ( TNFAIP3)

U2 - 10.1038/ng.2007.32

DO - 10.1038/ng.2007.32

M3 - Article

SN - 1546-1718

VL - 39

SP - 1431

EP - 1433

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

Rheumatoid arthritis association at 6q23

Abstract

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