Rhinovirus infection and healthcare utilisation in prematurely born infants

Simon B Drysdale; Mireia Alcazar-Paris; Theresa Wilson; Melvyn Smith; Mark Zuckerman; Simon Broughton; Gerrard F Rafferty; Janet L Peacock; Sebastian L Johnston; Anne Greenough

doi:10.1183/09031936.00109012

Rhinovirus infection and healthcare utilisation in prematurely born infants

Simon B Drysdale, Mireia Alcazar-Paris, Theresa Wilson, Melvyn Smith, Mark Zuckerman, Simon Broughton, Gerrard F Rafferty, Janet L Peacock, Sebastian L Johnston, Anne Greenough

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Do rhinovirus lower respiratory tract infections (RV) LRTIs in prematurely born infants increase health related cost of care during infancy? Patients and methods: 153 infants born <36 weeks of gestation were prospectively followed to one year. Cost of care was calculated from the NHS reference costing scheme and health care utilisation determined by examining hospital/general practitioner records.

Twenty infants developed RV LRTIs (RV group), 17 RSV LRTIs (RSV group), 12 both RV and RSV LRTIs (RV/RSV group), 74 had no LRTI (no LRTI group). Compared to the no LRTI group, the RV/RSV LRTI group had the greatest increase in adjusted mean cost (difference=£5769), followed by the RV LRTI group (difference=£278), then the RSV LRTI group (difference=£172), p=0.045. The RV group had more out-patient (p<0.05) and respiratory related general practitioner (p<0.05) attendances and more wheezed at follow up (p<0.001) than the no LRTI group and more respiratory related out-patient attendances than the RSV LRTI group (p<0.05). Answer to the question: RV LRTIs were associated with increased health related cost of care during infancy; our results suggest that the RV compared to the RSV group suffered greater chronic respiratory morbidity.

Original language	English
Pages (from-to)	1029-1036
Number of pages	8
Journal	European Respiratory Journal
Volume	42
Issue number	4
DOIs	https://doi.org/10.1183/09031936.00109012
Publication status	Published - 1 Oct 2013

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title = "Rhinovirus infection and healthcare utilisation in prematurely born infants",

abstract = "Do rhinovirus lower respiratory tract infections (RV) LRTIs in prematurely born infants increase health related cost of care during infancy? Patients and methods: 153 infants born <36 weeks of gestation were prospectively followed to one year. Cost of care was calculated from the NHS reference costing scheme and health care utilisation determined by examining hospital/general practitioner records.Twenty infants developed RV LRTIs (RV group), 17 RSV LRTIs (RSV group), 12 both RV and RSV LRTIs (RV/RSV group), 74 had no LRTI (no LRTI group). Compared to the no LRTI group, the RV/RSV LRTI group had the greatest increase in adjusted mean cost (difference=£5769), followed by the RV LRTI group (difference=£278), then the RSV LRTI group (difference=£172), p=0.045. The RV group had more out-patient (p<0.05) and respiratory related general practitioner (p<0.05) attendances and more wheezed at follow up (p<0.001) than the no LRTI group and more respiratory related out-patient attendances than the RSV LRTI group (p<0.05). Answer to the question: RV LRTIs were associated with increased health related cost of care during infancy; our results suggest that the RV compared to the RSV group suffered greater chronic respiratory morbidity.",

author = "Drysdale, {Simon B} and Mireia Alcazar-Paris and Theresa Wilson and Melvyn Smith and Mark Zuckerman and Simon Broughton and Rafferty, {Gerrard F} and Peacock, {Janet L} and Johnston, {Sebastian L} and Anne Greenough",

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doi = "10.1183/09031936.00109012",

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AU - Drysdale, Simon B

AU - Alcazar-Paris, Mireia

AU - Wilson, Theresa

AU - Smith, Melvyn

AU - Zuckerman, Mark

AU - Broughton, Simon

AU - Rafferty, Gerrard F

AU - Peacock, Janet L

AU - Johnston, Sebastian L

AU - Greenough, Anne

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Do rhinovirus lower respiratory tract infections (RV) LRTIs in prematurely born infants increase health related cost of care during infancy? Patients and methods: 153 infants born <36 weeks of gestation were prospectively followed to one year. Cost of care was calculated from the NHS reference costing scheme and health care utilisation determined by examining hospital/general practitioner records.Twenty infants developed RV LRTIs (RV group), 17 RSV LRTIs (RSV group), 12 both RV and RSV LRTIs (RV/RSV group), 74 had no LRTI (no LRTI group). Compared to the no LRTI group, the RV/RSV LRTI group had the greatest increase in adjusted mean cost (difference=£5769), followed by the RV LRTI group (difference=£278), then the RSV LRTI group (difference=£172), p=0.045. The RV group had more out-patient (p<0.05) and respiratory related general practitioner (p<0.05) attendances and more wheezed at follow up (p<0.001) than the no LRTI group and more respiratory related out-patient attendances than the RSV LRTI group (p<0.05). Answer to the question: RV LRTIs were associated with increased health related cost of care during infancy; our results suggest that the RV compared to the RSV group suffered greater chronic respiratory morbidity.

AB - Do rhinovirus lower respiratory tract infections (RV) LRTIs in prematurely born infants increase health related cost of care during infancy? Patients and methods: 153 infants born <36 weeks of gestation were prospectively followed to one year. Cost of care was calculated from the NHS reference costing scheme and health care utilisation determined by examining hospital/general practitioner records.Twenty infants developed RV LRTIs (RV group), 17 RSV LRTIs (RSV group), 12 both RV and RSV LRTIs (RV/RSV group), 74 had no LRTI (no LRTI group). Compared to the no LRTI group, the RV/RSV LRTI group had the greatest increase in adjusted mean cost (difference=£5769), followed by the RV LRTI group (difference=£278), then the RSV LRTI group (difference=£172), p=0.045. The RV group had more out-patient (p<0.05) and respiratory related general practitioner (p<0.05) attendances and more wheezed at follow up (p<0.001) than the no LRTI group and more respiratory related out-patient attendances than the RSV LRTI group (p<0.05). Answer to the question: RV LRTIs were associated with increased health related cost of care during infancy; our results suggest that the RV compared to the RSV group suffered greater chronic respiratory morbidity.

U2 - 10.1183/09031936.00109012

DO - 10.1183/09031936.00109012

M3 - Article

C2 - 23563263

SN - 0903-1936

VL - 42

SP - 1029

EP - 1036

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 4

ER -

Rhinovirus infection and healthcare utilisation in prematurely born infants

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