Rifampicin in the treatment of severe intrahepatic cholestasis of pregnancy

Victoria Geenes; Jenny Chambers; Rshmi Khurana; Elisabeth Wikstrom Shemer; Winnie Sia; Dalvinder Mandair; Elwyn Elias; Hanns-Ulrich Marschall; William Hague; Catherine Williamson

doi:10.1016/j.ejogrb.2015.03.020

Rifampicin in the treatment of severe intrahepatic cholestasis of pregnancy

Victoria Geenes, Jenny Chambers, Rshmi Khurana, Elisabeth Wikstrom Shemer, Winnie Sia, Dalvinder Mandair, Elwyn Elias, Hanns-Ulrich Marschall, William Hague, Catherine Williamson

Women & Children's Health

Research output: Contribution to journal › Article › peer-review

79 Citations (Scopus)

Abstract

OBJECTIVE: To describe the use of combined ursodeoxycholic acid (UDCA) and rifampicin treatment in intrahepatic cholestasis of pregnancy (ICP).

STUDY DESIGN: A questionnaire survey of 27 women with 28 affected pregnancies identified via the UK and International Obstetric Medicine forum. The clinical case notes of women with ICP treated with combined UDCA and rifampicin therapy were reviewed, and data regarding maternal and perinatal outcomes extracted.

RESULTS: Serum bile acids remained high whilst taking UDCA as monotherapy. In 14 pregnancies (54%) serum bile acids decreased following the introduction of rifampicin. In 10 pregnancies (38%), there was a 50% reduction in serum bile acids. There were no adverse effects reported with either drug.

CONCLUSIONS: This is the first report of the use of rifampicin in ICP. The data suggest that combined treatment with UDCA and rifampicin is an effective way of treating women with severe ICP who do not respond to treatment with UDCA alone.

Original language	English
Pages (from-to)	59-63
Number of pages	5
Journal	European Journal of Obstetrics Gynecology and Reproductive Biology
Volume	189
DOIs	https://doi.org/10.1016/j.ejogrb.2015.03.020
Publication status	Published - Jun 2015

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10.1016/j.ejogrb.2015.03.020

Cite this

@article{030274cd6e1c415bb0d10887825e2fc6,

title = "Rifampicin in the treatment of severe intrahepatic cholestasis of pregnancy",

abstract = "OBJECTIVE: To describe the use of combined ursodeoxycholic acid (UDCA) and rifampicin treatment in intrahepatic cholestasis of pregnancy (ICP).STUDY DESIGN: A questionnaire survey of 27 women with 28 affected pregnancies identified via the UK and International Obstetric Medicine forum. The clinical case notes of women with ICP treated with combined UDCA and rifampicin therapy were reviewed, and data regarding maternal and perinatal outcomes extracted.RESULTS: Serum bile acids remained high whilst taking UDCA as monotherapy. In 14 pregnancies (54%) serum bile acids decreased following the introduction of rifampicin. In 10 pregnancies (38%), there was a 50% reduction in serum bile acids. There were no adverse effects reported with either drug.CONCLUSIONS: This is the first report of the use of rifampicin in ICP. The data suggest that combined treatment with UDCA and rifampicin is an effective way of treating women with severe ICP who do not respond to treatment with UDCA alone.",

author = "Victoria Geenes and Jenny Chambers and Rshmi Khurana and Shemer, {Elisabeth Wikstrom} and Winnie Sia and Dalvinder Mandair and Elwyn Elias and Hanns-Ulrich Marschall and William Hague and Catherine Williamson",

year = "2015",

month = jun,

doi = "10.1016/j.ejogrb.2015.03.020",

language = "English",

volume = "189",

pages = "59--63",

journal = "European Journal of Obstetrics Gynecology and Reproductive Biology",

issn = "0301-2115",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Rifampicin in the treatment of severe intrahepatic cholestasis of pregnancy

AU - Geenes, Victoria

AU - Chambers, Jenny

AU - Khurana, Rshmi

AU - Shemer, Elisabeth Wikstrom

AU - Sia, Winnie

AU - Mandair, Dalvinder

AU - Elias, Elwyn

AU - Marschall, Hanns-Ulrich

AU - Hague, William

AU - Williamson, Catherine

PY - 2015/6

Y1 - 2015/6

N2 - OBJECTIVE: To describe the use of combined ursodeoxycholic acid (UDCA) and rifampicin treatment in intrahepatic cholestasis of pregnancy (ICP).STUDY DESIGN: A questionnaire survey of 27 women with 28 affected pregnancies identified via the UK and International Obstetric Medicine forum. The clinical case notes of women with ICP treated with combined UDCA and rifampicin therapy were reviewed, and data regarding maternal and perinatal outcomes extracted.RESULTS: Serum bile acids remained high whilst taking UDCA as monotherapy. In 14 pregnancies (54%) serum bile acids decreased following the introduction of rifampicin. In 10 pregnancies (38%), there was a 50% reduction in serum bile acids. There were no adverse effects reported with either drug.CONCLUSIONS: This is the first report of the use of rifampicin in ICP. The data suggest that combined treatment with UDCA and rifampicin is an effective way of treating women with severe ICP who do not respond to treatment with UDCA alone.

AB - OBJECTIVE: To describe the use of combined ursodeoxycholic acid (UDCA) and rifampicin treatment in intrahepatic cholestasis of pregnancy (ICP).STUDY DESIGN: A questionnaire survey of 27 women with 28 affected pregnancies identified via the UK and International Obstetric Medicine forum. The clinical case notes of women with ICP treated with combined UDCA and rifampicin therapy were reviewed, and data regarding maternal and perinatal outcomes extracted.RESULTS: Serum bile acids remained high whilst taking UDCA as monotherapy. In 14 pregnancies (54%) serum bile acids decreased following the introduction of rifampicin. In 10 pregnancies (38%), there was a 50% reduction in serum bile acids. There were no adverse effects reported with either drug.CONCLUSIONS: This is the first report of the use of rifampicin in ICP. The data suggest that combined treatment with UDCA and rifampicin is an effective way of treating women with severe ICP who do not respond to treatment with UDCA alone.

U2 - 10.1016/j.ejogrb.2015.03.020

DO - 10.1016/j.ejogrb.2015.03.020

M3 - Article

C2 - 25864112

SN - 0301-2115

VL - 189

SP - 59

EP - 63

JO - European Journal of Obstetrics Gynecology and Reproductive Biology

JF - European Journal of Obstetrics Gynecology and Reproductive Biology

ER -