Role of nitric oxide in posthypoxic contractile dysfunction of diabetic cardiomyopathy

M M El-Omar; R Lord; N J Draper; A A Shah

doi:10.1016/S1388-9842(03)00010-2

Role of nitric oxide in posthypoxic contractile dysfunction of diabetic cardiomyopathy

M M El-Omar, R Lord, N J Draper, A A Shah

King's College London

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

We investigated the role of nitric oxide synthase (NOS) in the contractile dysfunction of diabetic cardiomyopathy, comparing streptozotocin-treated (60 mg/kg) diabetic Wistar rats with matched non-diabetic controls. Isolated isovolumic heart function was studied during normoxia and in response to brief hypoxia-reoxygenation. Diabetic hearts had significantly lower left-ventricular pressure and slower isovolumic relaxation than controls (relaxation time constant, T 40.2+/-2.3 vs. 27.7+/-0.9 ms; P

Original language	English
Pages (from-to)	229 - 239
Number of pages	11
Journal	EUROPEAN JOURNAL OF HEART FAILURE
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/S1388-9842(03)00010-2
Publication status	Published - 2003

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Role of nitric oxide in posthypoxic contractile dysfunction of diabetic cardiomyopathy

Abstract

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