Role of the Notch signalling pathway in tooth morphogenesis.

T A Mitsiadis; L Regaudiat; T Gridley

doi:10.1016/j.archoralbio.2004.10.006

Role of the Notch signalling pathway in tooth morphogenesis.

T A Mitsiadis, L Regaudiat, T Gridley

King's College London

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Notch receptors are involved in cell fate decisions through the process of lateral inhibition or inductive signalling. Jagged2 belongs to the family of transmembrane proteins that serve as the ligands for Notch receptors. We have analysed the expression of the Jagged2 gene in developing mouse teeth. Jagged2 expression is restricted in inner enamel epithelial cells that give rise to the ameloblasts. We have also examined the role of Jagged2 in tooth development using mutant mice that lack the domain of the Jagged2 protein required for interaction with the Notch receptors (DSL domain). Homozygous mutant mice die after birth, exhibit abnormal tooth morphology and fusions between the palatal and mandibular shelves. These results demonstrate that Notch signalling plays an essential role in tooth development. (c) 2004 Elsevier Ltd. All rights reserved

Original language	English
Pages (from-to)	137 - 140
Number of pages	4
Journal	Archives of Oral Biology
Volume	50
Issue number	2
DOIs	https://doi.org/10.1016/j.archoralbio.2004.10.006
Publication status	Published - Feb 2005

Access to Document

10.1016/j.archoralbio.2004.10.006

Cite this

@article{b40dbb73c5474aafa5f5a805d252500f,

title = "Role of the Notch signalling pathway in tooth morphogenesis.",

abstract = "Notch receptors are involved in cell fate decisions through the process of lateral inhibition or inductive signalling. Jagged2 belongs to the family of transmembrane proteins that serve as the ligands for Notch receptors. We have analysed the expression of the Jagged2 gene in developing mouse teeth. Jagged2 expression is restricted in inner enamel epithelial cells that give rise to the ameloblasts. We have also examined the role of Jagged2 in tooth development using mutant mice that lack the domain of the Jagged2 protein required for interaction with the Notch receptors (DSL domain). Homozygous mutant mice die after birth, exhibit abnormal tooth morphology and fusions between the palatal and mandibular shelves. These results demonstrate that Notch signalling plays an essential role in tooth development. (c) 2004 Elsevier Ltd. All rights reserved",

author = "Mitsiadis, {T A} and L Regaudiat and T Gridley",

year = "2005",

month = feb,

doi = "10.1016/j.archoralbio.2004.10.006",

language = "English",

volume = "50",

pages = "137 -- 140",

journal = "Archives of Oral Biology",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Role of the Notch signalling pathway in tooth morphogenesis.

AU - Mitsiadis, T A

AU - Regaudiat, L

AU - Gridley, T

PY - 2005/2

Y1 - 2005/2

N2 - Notch receptors are involved in cell fate decisions through the process of lateral inhibition or inductive signalling. Jagged2 belongs to the family of transmembrane proteins that serve as the ligands for Notch receptors. We have analysed the expression of the Jagged2 gene in developing mouse teeth. Jagged2 expression is restricted in inner enamel epithelial cells that give rise to the ameloblasts. We have also examined the role of Jagged2 in tooth development using mutant mice that lack the domain of the Jagged2 protein required for interaction with the Notch receptors (DSL domain). Homozygous mutant mice die after birth, exhibit abnormal tooth morphology and fusions between the palatal and mandibular shelves. These results demonstrate that Notch signalling plays an essential role in tooth development. (c) 2004 Elsevier Ltd. All rights reserved

AB - Notch receptors are involved in cell fate decisions through the process of lateral inhibition or inductive signalling. Jagged2 belongs to the family of transmembrane proteins that serve as the ligands for Notch receptors. We have analysed the expression of the Jagged2 gene in developing mouse teeth. Jagged2 expression is restricted in inner enamel epithelial cells that give rise to the ameloblasts. We have also examined the role of Jagged2 in tooth development using mutant mice that lack the domain of the Jagged2 protein required for interaction with the Notch receptors (DSL domain). Homozygous mutant mice die after birth, exhibit abnormal tooth morphology and fusions between the palatal and mandibular shelves. These results demonstrate that Notch signalling plays an essential role in tooth development. (c) 2004 Elsevier Ltd. All rights reserved

U2 - 10.1016/j.archoralbio.2004.10.006

DO - 10.1016/j.archoralbio.2004.10.006

M3 - Article

VL - 50

SP - 137

EP - 140

JO - Archives of Oral Biology

JF - Archives of Oral Biology

IS - 2

ER -

Role of the Notch signalling pathway in tooth morphogenesis.

Abstract

Access to Document

Fingerprint

Cite this