Role of WASP in cell polarity and podosome dynamics of myeloid cells

James Monypenny; Hsiu-Chuan Chou; Inmaculada Banon-Rodriguez; Adrian J. Thrasher; Ines M. Anton; Gareth E. Jones; Yolanda Calle

doi:10.1016/j.ejcb.2010.05.009

Role of WASP in cell polarity and podosome dynamics of myeloid cells

James Monypenny, Hsiu-Chuan Chou, Inmaculada Banon-Rodriguez, Adrian J. Thrasher, Ines M. Anton, Gareth E. Jones, Yolanda Calle

Research output: Contribution to journal › Literature review › peer-review

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Abstract

The integrin-dependent migration of myeloid cells requires tight coordination between actin-based cell membrane protrusion and integrin-mediated adhesion to form a stable leading edge. Under this mode of migration, polarised myeloid cells including dendritic cells, macrophages and osteoclasts develop podosomes that sustain the extending leading edge. Podosome integrity and dynamics vary in response to changes in the physical and biochemical properties of the cell environment. In the current article we discuss the role of various factors in initiation and stability of podosomes and the roles of the Wiskott Aldrich Syndrome Protein (WASP) in this process. We discuss recent data indicating that in a cellular context WASP is crucial not only for localised actin polymerisation at the leading edge and in podosome cores but also for coordination of integrin clustering and activation during podosome formation and disassembly. (C) 2010 Elsevier GmbH. All rights reserved.

Original language	English
Pages (from-to)	198 - 204
Number of pages	7
Journal	European Journal of Cell Biology
Volume	90
Issue number	2-3
Early online date	6 Jul 2010
DOIs	https://doi.org/10.1016/j.ejcb.2010.05.009
Publication status	Published - Feb 2011

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Role of WASP in cell_MONYPENNY_Acc14May2010Epub6Jul2010_GOLD VoR (CC BY)Final published version, 1.51 MBLicence: CC BY

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title = "Role of WASP in cell polarity and podosome dynamics of myeloid cells",

abstract = "The integrin-dependent migration of myeloid cells requires tight coordination between actin-based cell membrane protrusion and integrin-mediated adhesion to form a stable leading edge. Under this mode of migration, polarised myeloid cells including dendritic cells, macrophages and osteoclasts develop podosomes that sustain the extending leading edge. Podosome integrity and dynamics vary in response to changes in the physical and biochemical properties of the cell environment. In the current article we discuss the role of various factors in initiation and stability of podosomes and the roles of the Wiskott Aldrich Syndrome Protein (WASP) in this process. We discuss recent data indicating that in a cellular context WASP is crucial not only for localised actin polymerisation at the leading edge and in podosome cores but also for coordination of integrin clustering and activation during podosome formation and disassembly. (C) 2010 Elsevier GmbH. All rights reserved.",

author = "James Monypenny and Hsiu-Chuan Chou and Inmaculada Banon-Rodriguez and Thrasher, {Adrian J.} and Anton, {Ines M.} and Jones, {Gareth E.} and Yolanda Calle",

year = "2011",

month = feb,

doi = "10.1016/j.ejcb.2010.05.009",

language = "English",

volume = "90",

pages = "198 -- 204",

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TY - JOUR

T1 - Role of WASP in cell polarity and podosome dynamics of myeloid cells

AU - Monypenny, James

AU - Chou, Hsiu-Chuan

AU - Banon-Rodriguez, Inmaculada

AU - Thrasher, Adrian J.

AU - Anton, Ines M.

AU - Jones, Gareth E.

AU - Calle, Yolanda

PY - 2011/2

Y1 - 2011/2

N2 - The integrin-dependent migration of myeloid cells requires tight coordination between actin-based cell membrane protrusion and integrin-mediated adhesion to form a stable leading edge. Under this mode of migration, polarised myeloid cells including dendritic cells, macrophages and osteoclasts develop podosomes that sustain the extending leading edge. Podosome integrity and dynamics vary in response to changes in the physical and biochemical properties of the cell environment. In the current article we discuss the role of various factors in initiation and stability of podosomes and the roles of the Wiskott Aldrich Syndrome Protein (WASP) in this process. We discuss recent data indicating that in a cellular context WASP is crucial not only for localised actin polymerisation at the leading edge and in podosome cores but also for coordination of integrin clustering and activation during podosome formation and disassembly. (C) 2010 Elsevier GmbH. All rights reserved.

AB - The integrin-dependent migration of myeloid cells requires tight coordination between actin-based cell membrane protrusion and integrin-mediated adhesion to form a stable leading edge. Under this mode of migration, polarised myeloid cells including dendritic cells, macrophages and osteoclasts develop podosomes that sustain the extending leading edge. Podosome integrity and dynamics vary in response to changes in the physical and biochemical properties of the cell environment. In the current article we discuss the role of various factors in initiation and stability of podosomes and the roles of the Wiskott Aldrich Syndrome Protein (WASP) in this process. We discuss recent data indicating that in a cellular context WASP is crucial not only for localised actin polymerisation at the leading edge and in podosome cores but also for coordination of integrin clustering and activation during podosome formation and disassembly. (C) 2010 Elsevier GmbH. All rights reserved.

U2 - 10.1016/j.ejcb.2010.05.009

DO - 10.1016/j.ejcb.2010.05.009

M3 - Literature review

VL - 90

SP - 198

EP - 204

JO - European Journal of Cell Biology

JF - European Journal of Cell Biology

IS - 2-3

ER -

Role of WASP in cell polarity and podosome dynamics of myeloid cells

Abstract

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