TY - JOUR
T1 - Rotary and linear molecular motors driven by pulses of a chemical fuel
AU - Erbas-Cakmak, Sundus
AU - Fielden, Stephen D.P.
AU - Karaca, Ulvi
AU - Leigh, David A.
AU - McTernan, Charlie T.
AU - Tetlow, Daniel J.
AU - Wilson, Miriam R.
N1 - Funding Information:
This research was funded by the European Research Council (Advanced grant 339019). We thank the Engineering and Physical Sciences Research Council National Mass Spectrometry Service Centre (Swansea, UK) for high-resolution mass spectrometry. D.A.L. is a Royal Society Research Professor. The data that support the findings of this study are available within the paper and its supplementary materials or from the Mendeley data repository with the identifier doi: 10.17632/8w3r64c3k3.1.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/10/20
Y1 - 2017/10/20
N2 - Many biomolecular motors catalyze the hydrolysis of chemical fuels, such as adenosine triphosphate, and use the energy released to direct motion through information ratchet mechanisms. Here we describe chemically-driven artificial rotary and linear molecular motors that operate through a fundamentally different type of mechanism. The directional rotation of [2]- and [3]catenane rotary molecular motors and the transport of substrates away from equilibrium by a linear molecular pump are induced by acid-base oscillations. The changes simultaneously switch the binding site affinities and the labilities of barriers on the track, creating an energy ratchet. The linear and rotary molecular motors are driven by aliquots of a chemical fuel, trichloroacetic acid. A single fuel pulse generates 360° unidirectional rotation of up to 87% of crown ethers in a [2]catenane rotary motor.
AB - Many biomolecular motors catalyze the hydrolysis of chemical fuels, such as adenosine triphosphate, and use the energy released to direct motion through information ratchet mechanisms. Here we describe chemically-driven artificial rotary and linear molecular motors that operate through a fundamentally different type of mechanism. The directional rotation of [2]- and [3]catenane rotary molecular motors and the transport of substrates away from equilibrium by a linear molecular pump are induced by acid-base oscillations. The changes simultaneously switch the binding site affinities and the labilities of barriers on the track, creating an energy ratchet. The linear and rotary molecular motors are driven by aliquots of a chemical fuel, trichloroacetic acid. A single fuel pulse generates 360° unidirectional rotation of up to 87% of crown ethers in a [2]catenane rotary motor.
UR - http://www.scopus.com/inward/record.url?scp=85032485812&partnerID=8YFLogxK
U2 - 10.1126/science.aao1377
DO - 10.1126/science.aao1377
M3 - Article
C2 - 29051374
AN - SCOPUS:85032485812
SN - 0036-8075
VL - 358
SP - 340
EP - 343
JO - Science
JF - Science
IS - 6361
ER -