Sensory gating deficits in the attenuated psychosis syndrome

Madiha Shaikh; Anirban Dutt; Matthew R Broome; Alberto G Vozmediano; Siri Ranlund; Alvaro Diez; Olalla Caseiro; Julia Lappin; Susan Amankwa; Francesco Carletti; Paolo Fusar-Poli; Muriel Walshe; Mei-Hua Hall; Oliver Howes; Lyn Ellett; Robin M Murray; Philip McGuire; Lucia Valmaggia; Elvira Bramon

doi:10.1016/j.schres.2014.12.021

Sensory gating deficits in the attenuated psychosis syndrome

Madiha Shaikh^*, Anirban Dutt, Matthew R Broome, Alberto G Vozmediano, Siri Ranlund, Alvaro Diez, Olalla Caseiro, Julia Lappin, Susan Amankwa, Francesco Carletti, Paolo Fusar-Poli, Muriel Walshe, Mei-Hua Hall, Oliver Howes, Lyn Ellett, Robin M Murray, Philip McGuire, Lucia Valmaggia, Elvira Bramon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

BACKGROUND: Individuals with an "Attenuated Psychosis Syndrome" (APS) have a 20-40% chance of developing a psychotic disorder within two years; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether P50 gating deficits could help to discriminate individuals with APS and also those who are particularly likely to make a transition to psychosis.

METHOD: 36 cases meeting PACE (Personal Assessment and Crisis Evaluation) criteria for the APS, all free of antipsychotics, and 60 controls performed an auditory conditioning-testing experiment while their electroencephalogram was recorded. The P50 ratio and its C-T difference were compared between groups. Subjects received follow-up for up to 2years to determine their clinical outcome.

RESULTS: The P50 ratio was significantly higher and C-T difference lower in the APS group compared to controls. Of the individuals with APS who completed the follow-up (n=36), nine (25%) developed psychosis. P50 ratio and the C-T difference did not significantly differ between those individuals who developed psychosis and those who did not within the APS group.

CONCLUSION: P50 deficits appear to be associated with the pre-clinical phase of psychosis. However, due to the limitations of the study and its sample size, replication in an independent cohort is necessary, to clarify the role of P50 deficits in illness progression and whether this inexpensive and non-invasive EEG marker could be of clinical value in the prediction of psychosis outcomes amongst populations at risk.

Original language	English
Pages (from-to)	277-282
Number of pages	6
Journal	Schizophrenia Research
Volume	161
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2014.12.021
Publication status	Published - Feb 2015

Keywords

APS
EEG
ERP
P50
Psychosis
Sensory-gating

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2014.12.021

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Shaikh, M., Dutt, A., Broome, M. R., Vozmediano, A. G., Ranlund, S., Diez, A., Caseiro, O., Lappin, J., Amankwa, S., Carletti, F., Fusar-Poli, P., Walshe, M., Hall, M.-H., Howes, O., Ellett, L., Murray, R. M., McGuire, P., Valmaggia, L., & Bramon, E. (2015). Sensory gating deficits in the attenuated psychosis syndrome. Schizophrenia Research, 161(2-3), 277-282. https://doi.org/10.1016/j.schres.2014.12.021

@article{385c06618f4e45d8914004f5afa42ab4,

title = "Sensory gating deficits in the attenuated psychosis syndrome",

abstract = "BACKGROUND: Individuals with an {"}Attenuated Psychosis Syndrome{"} (APS) have a 20-40% chance of developing a psychotic disorder within two years; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether P50 gating deficits could help to discriminate individuals with APS and also those who are particularly likely to make a transition to psychosis.METHOD: 36 cases meeting PACE (Personal Assessment and Crisis Evaluation) criteria for the APS, all free of antipsychotics, and 60 controls performed an auditory conditioning-testing experiment while their electroencephalogram was recorded. The P50 ratio and its C-T difference were compared between groups. Subjects received follow-up for up to 2years to determine their clinical outcome.RESULTS: The P50 ratio was significantly higher and C-T difference lower in the APS group compared to controls. Of the individuals with APS who completed the follow-up (n=36), nine (25%) developed psychosis. P50 ratio and the C-T difference did not significantly differ between those individuals who developed psychosis and those who did not within the APS group.CONCLUSION: P50 deficits appear to be associated with the pre-clinical phase of psychosis. However, due to the limitations of the study and its sample size, replication in an independent cohort is necessary, to clarify the role of P50 deficits in illness progression and whether this inexpensive and non-invasive EEG marker could be of clinical value in the prediction of psychosis outcomes amongst populations at risk.",

keywords = "APS, EEG, ERP, P50, Psychosis, Sensory-gating",

author = "Madiha Shaikh and Anirban Dutt and Broome, {Matthew R} and Vozmediano, {Alberto G} and Siri Ranlund and Alvaro Diez and Olalla Caseiro and Julia Lappin and Susan Amankwa and Francesco Carletti and Paolo Fusar-Poli and Muriel Walshe and Mei-Hua Hall and Oliver Howes and Lyn Ellett and Murray, {Robin M} and Philip McGuire and Lucia Valmaggia and Elvira Bramon",

year = "2015",

month = feb,

doi = "10.1016/j.schres.2014.12.021",

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Shaikh, M , Dutt, A, Broome, MR, Vozmediano, AG, Ranlund, S, Diez, A, Caseiro, O, Lappin, J, Amankwa, S, Carletti, F , Fusar-Poli, P , Walshe, M, Hall, M-H, Howes, O, Ellett, L, Murray, RM , McGuire, P , Valmaggia, L & Bramon, E 2015, 'Sensory gating deficits in the attenuated psychosis syndrome', Schizophrenia Research, vol. 161, no. 2-3, pp. 277-282. https://doi.org/10.1016/j.schres.2014.12.021

TY - JOUR

T1 - Sensory gating deficits in the attenuated psychosis syndrome

AU - Shaikh, Madiha

AU - Dutt, Anirban

AU - Broome, Matthew R

AU - Vozmediano, Alberto G

AU - Ranlund, Siri

AU - Diez, Alvaro

AU - Caseiro, Olalla

AU - Lappin, Julia

AU - Amankwa, Susan

AU - Carletti, Francesco

AU - Fusar-Poli, Paolo

AU - Walshe, Muriel

AU - Hall, Mei-Hua

AU - Howes, Oliver

AU - Ellett, Lyn

AU - Murray, Robin M

AU - McGuire, Philip

AU - Valmaggia, Lucia

AU - Bramon, Elvira

PY - 2015/2

Y1 - 2015/2

N2 - BACKGROUND: Individuals with an "Attenuated Psychosis Syndrome" (APS) have a 20-40% chance of developing a psychotic disorder within two years; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether P50 gating deficits could help to discriminate individuals with APS and also those who are particularly likely to make a transition to psychosis.METHOD: 36 cases meeting PACE (Personal Assessment and Crisis Evaluation) criteria for the APS, all free of antipsychotics, and 60 controls performed an auditory conditioning-testing experiment while their electroencephalogram was recorded. The P50 ratio and its C-T difference were compared between groups. Subjects received follow-up for up to 2years to determine their clinical outcome.RESULTS: The P50 ratio was significantly higher and C-T difference lower in the APS group compared to controls. Of the individuals with APS who completed the follow-up (n=36), nine (25%) developed psychosis. P50 ratio and the C-T difference did not significantly differ between those individuals who developed psychosis and those who did not within the APS group.CONCLUSION: P50 deficits appear to be associated with the pre-clinical phase of psychosis. However, due to the limitations of the study and its sample size, replication in an independent cohort is necessary, to clarify the role of P50 deficits in illness progression and whether this inexpensive and non-invasive EEG marker could be of clinical value in the prediction of psychosis outcomes amongst populations at risk.

AB - BACKGROUND: Individuals with an "Attenuated Psychosis Syndrome" (APS) have a 20-40% chance of developing a psychotic disorder within two years; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether P50 gating deficits could help to discriminate individuals with APS and also those who are particularly likely to make a transition to psychosis.METHOD: 36 cases meeting PACE (Personal Assessment and Crisis Evaluation) criteria for the APS, all free of antipsychotics, and 60 controls performed an auditory conditioning-testing experiment while their electroencephalogram was recorded. The P50 ratio and its C-T difference were compared between groups. Subjects received follow-up for up to 2years to determine their clinical outcome.RESULTS: The P50 ratio was significantly higher and C-T difference lower in the APS group compared to controls. Of the individuals with APS who completed the follow-up (n=36), nine (25%) developed psychosis. P50 ratio and the C-T difference did not significantly differ between those individuals who developed psychosis and those who did not within the APS group.CONCLUSION: P50 deficits appear to be associated with the pre-clinical phase of psychosis. However, due to the limitations of the study and its sample size, replication in an independent cohort is necessary, to clarify the role of P50 deficits in illness progression and whether this inexpensive and non-invasive EEG marker could be of clinical value in the prediction of psychosis outcomes amongst populations at risk.

KW - APS

KW - EEG

KW - ERP

KW - P50

KW - Psychosis

KW - Sensory-gating

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U2 - 10.1016/j.schres.2014.12.021

DO - 10.1016/j.schres.2014.12.021

M3 - Article

C2 - 25556079

SN - 0920-9964

VL - 161

SP - 277

EP - 282

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 2-3

ER -

Sensory gating deficits in the attenuated psychosis syndrome

Abstract

Keywords

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