Serotonergic polymorphisms and psychotic disorders in populations from North Spain

I Mata; M J Arranz; A Patino; T Lai; M Beperet; L Sierrasesumaga; D Clark; F Perez-Nievas; L Richards; F Ortuno; P Sham; R W Kerwin

doi:10.1002/ajmg.b.20150

Serotonergic polymorphisms and psychotic disorders in populations from North Spain

I Mata, M J Arranz, A Patino, T Lai, M Beperet, L Sierrasesumaga, D Clark, F Perez-Nievas, L Richards, F Ortuno, P Sham, R W Kerwin

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27 Citations (Scopus)

Abstract

There is strong biological evidence relating alterations in the serotonergic system with mental disorders. These alterations may be originated at the DNA level by sequence mutations that alter the functioning of serotonin receptors and transporter. To test this hypothesis we investigated three genetic variants of the 5-HT2A receptor (-1438G/A, 102T/C and His452Tyr) and two variants of the serotonin transporter (a VNTR in the second intron and a 44 bp insertion/delition in the promoter region of the gene) in a clinical sample recruited in a human isolate and in surrounding areas in Northern Spain (N=257) and in ethnically matched controls (N=334). No clear association was found between 5-HT2A variants and psychosis. However, marginal associations were observed between the 5-HTT LPR and VNTR variants and psychosis (Pless than or equal to0.05) indicating a minor contribution to psychosis of genetic alterations in this gene. (C) 2003 Wiley-Liss, Inc.

Original language	English
Pages (from-to)	88 - 94
Number of pages	7
Journal	American Journal of Medical Genetics
Volume	126B
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.b.20150
Publication status	Published - 1 Apr 2004

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abstract = "There is strong biological evidence relating alterations in the serotonergic system with mental disorders. These alterations may be originated at the DNA level by sequence mutations that alter the functioning of serotonin receptors and transporter. To test this hypothesis we investigated three genetic variants of the 5-HT2A receptor (-1438G/A, 102T/C and His452Tyr) and two variants of the serotonin transporter (a VNTR in the second intron and a 44 bp insertion/delition in the promoter region of the gene) in a clinical sample recruited in a human isolate and in surrounding areas in Northern Spain (N=257) and in ethnically matched controls (N=334). No clear association was found between 5-HT2A variants and psychosis. However, marginal associations were observed between the 5-HTT LPR and VNTR variants and psychosis (Pless than or equal to0.05) indicating a minor contribution to psychosis of genetic alterations in this gene. (C) 2003 Wiley-Liss, Inc.",

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AU - Mata, I

AU - Arranz, M J

AU - Patino, A

AU - Lai, T

AU - Beperet, M

AU - Sierrasesumaga, L

AU - Clark, D

AU - Perez-Nievas, F

AU - Richards, L

AU - Ortuno, F

AU - Sham, P

AU - Kerwin, R W

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N2 - There is strong biological evidence relating alterations in the serotonergic system with mental disorders. These alterations may be originated at the DNA level by sequence mutations that alter the functioning of serotonin receptors and transporter. To test this hypothesis we investigated three genetic variants of the 5-HT2A receptor (-1438G/A, 102T/C and His452Tyr) and two variants of the serotonin transporter (a VNTR in the second intron and a 44 bp insertion/delition in the promoter region of the gene) in a clinical sample recruited in a human isolate and in surrounding areas in Northern Spain (N=257) and in ethnically matched controls (N=334). No clear association was found between 5-HT2A variants and psychosis. However, marginal associations were observed between the 5-HTT LPR and VNTR variants and psychosis (Pless than or equal to0.05) indicating a minor contribution to psychosis of genetic alterations in this gene. (C) 2003 Wiley-Liss, Inc.

AB - There is strong biological evidence relating alterations in the serotonergic system with mental disorders. These alterations may be originated at the DNA level by sequence mutations that alter the functioning of serotonin receptors and transporter. To test this hypothesis we investigated three genetic variants of the 5-HT2A receptor (-1438G/A, 102T/C and His452Tyr) and two variants of the serotonin transporter (a VNTR in the second intron and a 44 bp insertion/delition in the promoter region of the gene) in a clinical sample recruited in a human isolate and in surrounding areas in Northern Spain (N=257) and in ethnically matched controls (N=334). No clear association was found between 5-HT2A variants and psychosis. However, marginal associations were observed between the 5-HTT LPR and VNTR variants and psychosis (Pless than or equal to0.05) indicating a minor contribution to psychosis of genetic alterations in this gene. (C) 2003 Wiley-Liss, Inc.

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JO - American Journal of Medical Genetics

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Serotonergic polymorphisms and psychotic disorders in populations from North Spain

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