@article{ec904dbfe6c74bb48535205b89f54cce,
title = "Seven newly identified loci for autoimmune thyroid disease",
abstract = "Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10-6; a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.",
author = "{Wellcome Trust Case Control Consortium} and Cooper, {Jason D.} and Simmonds, {Matthew J.} and Walker, {Neil M.} and Oliver Burren and Brand, {Oliver J.} and Hui Guo and Chris Wallace and Helen Stevens and Gillian Coleman and Franklyn, {Jayne A.} and Todd, {John A.} and Gough, {Stephen C.L.} and Jan Aerts and Tariq Ahmad and Hazel Arbury and Anthony Attwood and Adam Auton and Ball, {Stephen G.} and Balmforth, {Anthony J.} and Chris Barnes and Barrett, {Jeffrey C.} and In{\^e}s Barroso and Anne Barton and Bennett, {Amanda J.} and Sanjeev Bhaskar and Katarzyna Blaszczyk and John Bowes and Braund, {Peter S.} and Francesca Bredin and Gerome Breen and Brown, {Morris J.} and Bruce, {Ian N.} and Jaswinder Bull and John Burton and Jake Byrnes and Sian Caesar and Niall Cardin and Clee, {Chris M.} and Coffey, {Alison J.} and Connell, {John M.C.} and Conrad, {Donald F.} and Dominiczak, {Anna F.} and Anne Farmer and Husam Hebaishi and Peter McGuffin and Prescott, {Natalie J.} and Sanderson, {Jeremy D.} and Sophia Steer and Young, {Allan H.} and Mathew, {Christopher G.}",
year = "2012",
month = dec,
day = "1",
doi = "10.1093/hmg/dds357",
language = "English",
volume = "21",
pages = "5202--5208",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "23",
}