Sex difference in brain CB1 receptor availability in man

Heikki Laurikainen; Lauri Tuominen; Maria Tikka; Harri Merisaari; Reetta-Liina Armio; Elina Sormunen; Faith Borgan; Mattia Veronese; Oliver Howes; Merja Haaparanta-Solin; Olof Solin; Jarmo Hietala

doi:10.1016/j.neuroimage.2018.10.013

Sex difference in brain CB1 receptor availability in man

Heikki Laurikainen, Lauri Tuominen, Maria Tikka, Harri Merisaari, Reetta-Liina Armio, Elina Sormunen, Faith Borgan, Mattia Veronese, Oliver Howes, Merja Haaparanta-Solin, Olof Solin, Jarmo Hietala

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

463 Downloads (Pure)

Abstract

The endocannabinoid system (ECS) has a widespread neuromodulatory function in the central nervous system and is involved in important aspects of brain function including brain development, cortical rhythms, plasticity, reward, and stress sensitivity. Many of these effects are mediated via the cannabinoid CB1 receptor (CB1R) subtype. Animal studies convincingly show an interaction between the ECS and sex hormones, as well as a sex difference of higher brain CB1R in males. Human in vivo studies of sex difference have yielded discrepant findings. Gender differences in CB1R availability were investigated in vivo in 11 male and 11 female healthy volunteers using a specific CB1R tracer [18F]FMPEP-d2 and positron emission tomography (PET). Regional [18F]FMPEP-d2 distribution volume was used as a proxy for CB1R availability. In addition, we explored whether CB1R availability is linked to neuropsychological functioning. Relative to females, CB1R availability was on average 41% higher in males (p = 0.002) with a regionally specific effect larger in the posterior cingulate and retrosplenial cortices (p = 0.001). Inter-subject variability in CB1R availability was similar in both groups. Voxel-based analyses revealed an inverse association between CB1R availability and visuospatial working memory task performance in both groups (p 

Original language	English
Journal	NeuroImage
Early online date	5 Oct 2018
DOIs	https://doi.org/10.1016/j.neuroimage.2018.10.013
Publication status	E-pub ahead of print - 5 Oct 2018

Keywords

Endocannabinoid
cb1 receptor
Sex difference
Working memory

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.neuroimage.2018.10.013

Sex difference in brain_TUOMINEN_Firstonline5October2018_GREEN AAM (CC BY-NC-ND)Accepted author manuscript, 2.32 MBLicence: CC BY-NC-ND

Cite this

@article{efef9d7be4bb43db8d6827b6b6f3e75e,

title = "Sex difference in brain CB1 receptor availability in man",

abstract = "The endocannabinoid system (ECS) has a widespread neuromodulatory function in the central nervous system and is involved in important aspects of brain function including brain development, cortical rhythms, plasticity, reward, and stress sensitivity. Many of these effects are mediated via the cannabinoid CB1 receptor (CB1R) subtype. Animal studies convincingly show an interaction between the ECS and sex hormones, as well as a sex difference of higher brain CB1R in males. Human in vivo studies of sex difference have yielded discrepant findings. Gender differences in CB1R availability were investigated in vivo in 11 male and 11 female healthy volunteers using a specific CB1R tracer [18F]FMPEP-d2 and positron emission tomography (PET). Regional [18F]FMPEP-d2 distribution volume was used as a proxy for CB1R availability. In addition, we explored whether CB1R availability is linked to neuropsychological functioning. Relative to females, CB1R availability was on average 41% higher in males (p = 0.002) with a regionally specific effect larger in the posterior cingulate and retrosplenial cortices (p = 0.001). Inter-subject variability in CB1R availability was similar in both groups. Voxel-based analyses revealed an inverse association between CB1R availability and visuospatial working memory task performance in both groups (p ",

keywords = "Endocannabinoid, cb1 receptor, Sex difference, Working memory",

author = "Heikki Laurikainen and Lauri Tuominen and Maria Tikka and Harri Merisaari and Reetta-Liina Armio and Elina Sormunen and Faith Borgan and Mattia Veronese and Oliver Howes and Merja Haaparanta-Solin and Olof Solin and Jarmo Hietala",

year = "2018",

month = oct,

day = "5",

doi = "10.1016/j.neuroimage.2018.10.013",

language = "English",

journal = "NeuroImage",

issn = "1053-8119",

publisher = "ACADEMIC PRESS INC ELSEVIER SCIENCE",

}

TY - JOUR

T1 - Sex difference in brain CB1 receptor availability in man

AU - Laurikainen, Heikki

AU - Tuominen, Lauri

AU - Tikka, Maria

AU - Merisaari, Harri

AU - Armio, Reetta-Liina

AU - Sormunen, Elina

AU - Borgan, Faith

AU - Veronese, Mattia

AU - Howes, Oliver

AU - Haaparanta-Solin, Merja

AU - Solin, Olof

AU - Hietala, Jarmo

PY - 2018/10/5

Y1 - 2018/10/5

N2 - The endocannabinoid system (ECS) has a widespread neuromodulatory function in the central nervous system and is involved in important aspects of brain function including brain development, cortical rhythms, plasticity, reward, and stress sensitivity. Many of these effects are mediated via the cannabinoid CB1 receptor (CB1R) subtype. Animal studies convincingly show an interaction between the ECS and sex hormones, as well as a sex difference of higher brain CB1R in males. Human in vivo studies of sex difference have yielded discrepant findings. Gender differences in CB1R availability were investigated in vivo in 11 male and 11 female healthy volunteers using a specific CB1R tracer [18F]FMPEP-d2 and positron emission tomography (PET). Regional [18F]FMPEP-d2 distribution volume was used as a proxy for CB1R availability. In addition, we explored whether CB1R availability is linked to neuropsychological functioning. Relative to females, CB1R availability was on average 41% higher in males (p = 0.002) with a regionally specific effect larger in the posterior cingulate and retrosplenial cortices (p = 0.001). Inter-subject variability in CB1R availability was similar in both groups. Voxel-based analyses revealed an inverse association between CB1R availability and visuospatial working memory task performance in both groups (p 

AB - The endocannabinoid system (ECS) has a widespread neuromodulatory function in the central nervous system and is involved in important aspects of brain function including brain development, cortical rhythms, plasticity, reward, and stress sensitivity. Many of these effects are mediated via the cannabinoid CB1 receptor (CB1R) subtype. Animal studies convincingly show an interaction between the ECS and sex hormones, as well as a sex difference of higher brain CB1R in males. Human in vivo studies of sex difference have yielded discrepant findings. Gender differences in CB1R availability were investigated in vivo in 11 male and 11 female healthy volunteers using a specific CB1R tracer [18F]FMPEP-d2 and positron emission tomography (PET). Regional [18F]FMPEP-d2 distribution volume was used as a proxy for CB1R availability. In addition, we explored whether CB1R availability is linked to neuropsychological functioning. Relative to females, CB1R availability was on average 41% higher in males (p = 0.002) with a regionally specific effect larger in the posterior cingulate and retrosplenial cortices (p = 0.001). Inter-subject variability in CB1R availability was similar in both groups. Voxel-based analyses revealed an inverse association between CB1R availability and visuospatial working memory task performance in both groups (p 

KW - Endocannabinoid

KW - cb1 receptor

KW - Sex difference

KW - Working memory

U2 - 10.1016/j.neuroimage.2018.10.013

DO - 10.1016/j.neuroimage.2018.10.013

M3 - Article

SN - 1053-8119

JO - NeuroImage

JF - NeuroImage

ER -

Sex difference in brain CB1 receptor availability in man

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this