Sex differences in CGRP-induced vasodilation of human middle meningeal arteries but not human coronary arteries: implications for migraine

Tessa de Vries, Deirdre M. Boucherie, Kayi Y. Chan, Eloísa Rubio-Beltrán, Alejandro Labastida-Ramírez, Sieneke Labruijere, Saurabh Gupta, Antoon van den Bogaerdt, Arnaud Vincent, Ruben Dammers, A. H.Jan Danser, Antoinette MaassenVanDenBrink

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

BACKGROUND: Migraine prevalence and levels of calcitonin gene-related peptide (CGRP), a peptide involved in migraine pathophysiology, differ between men and women, and appear to be affected by changes in sex hormones. The present study investigated the sex-specific responses to CGRP in human isolated arteries. METHODS: CGRP-induced relaxation of 62 (28 men and 34 women) human isolated middle meningeal arteries (HMMA) and 139 (69 men and 70 women) human isolated coronary arteries (HCA) was compared between men and women in groups <50 years and ≥50 years of age as a proxy for pre- and postmenopausal status in women, as well as matched-age groups for men. RESULTS: In HCA, no differences were observed between male and female tissue, or between the different age groups. However, in HMMA, the maximum response was significantly smaller and CGRP was less potent in females <50 compared with males <50 years of age. No differences were observed between the older age groups. CONCLUSIONS: Sex differences were observed for CGRP-induced relaxation of HMMA, but not HCA. These differences could arise from differential receptor expression in the vascular beds combined with the effect of sex hormones on CGRP and subsequent receptor desensitization.

Original languageEnglish
Pages (from-to)3331024241254088
JournalCephalalgia : an international journal of headache
Volume44
Issue number7
DOIs
Publication statusPublished - 24 Jul 2024

Keywords

  • Humans
  • Female
  • Male
  • Middle Aged
  • Calcitonin Gene-Related Peptide/pharmacology
  • Migraine Disorders/physiopathology
  • Meningeal Arteries/drug effects
  • Vasodilation/physiology
  • Adult
  • Coronary Vessels/drug effects
  • Sex Characteristics
  • Aged

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