Shorter spontaneous fixation durations in infants with later emerging autism

Sam V. Wass; Emily J. H. Jones; Teodora Gliga; Tim J. Smith; Tony Charman; Mark H. Johnson; BASIS Team

doi:10.1038/srep08284

Shorter spontaneous fixation durations in infants with later emerging autism

Sam V. Wass, Emily J. H. Jones, Teodora Gliga, Tim J. Smith, Tony Charman, Mark H. Johnson, BASIS Team

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Abstract

Little is known about how spontaneous attentional deployment differs on a millisecond-level scale in the early development of autism spectrum disorders (ASD). We measured fine-grained eye movement patterns in 6-to 9-month-old infants at high or low familial risk (HR/LR) of ASD while they viewed static images. We observed shorter fixation durations (i.e. the time interval between saccades) in HR than LR infants. Preliminary analyses indicate that these results were replicated in a second cohort of infants. Fixation durations were shortest in those infants who went on to receive an ASD diagnosis at 36 months. While these findings demonstrate early-developing atypicality in fine-grained measures of attentional deployment early in the etiology of ASD, the specificity of these effects to ASD remains to be determined.

Original language	English
Article number	8284
Number of pages	8
Journal	Scientific Reports
Volume	5
Early online date	6 Feb 2015
DOIs	https://doi.org/10.1038/srep08284
Publication status	E-pub ahead of print - 6 Feb 2015

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title = "Shorter spontaneous fixation durations in infants with later emerging autism",

abstract = "Little is known about how spontaneous attentional deployment differs on a millisecond-level scale in the early development of autism spectrum disorders (ASD). We measured fine-grained eye movement patterns in 6-to 9-month-old infants at high or low familial risk (HR/LR) of ASD while they viewed static images. We observed shorter fixation durations (i.e. the time interval between saccades) in HR than LR infants. Preliminary analyses indicate that these results were replicated in a second cohort of infants. Fixation durations were shortest in those infants who went on to receive an ASD diagnosis at 36 months. While these findings demonstrate early-developing atypicality in fine-grained measures of attentional deployment early in the etiology of ASD, the specificity of these effects to ASD remains to be determined.",

author = "Wass, {Sam V.} and Jones, {Emily J. H.} and Teodora Gliga and Smith, {Tim J.} and Tony Charman and Johnson, {Mark H.} and {BASIS Team} and Simon Baron-cohen and Rachael Bedford and Patrick Bolton and Susie Chandler and Kim Davies and Janice Fernandes and Holly Garwood and Kristelle Hudry and Helen Maris and Greg Pasco and Andrew Pickles and Helena Ribiero and Leslie Tucker and Agnes Volein",

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language = "English",

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TY - JOUR

T1 - Shorter spontaneous fixation durations in infants with later emerging autism

AU - Wass, Sam V.

AU - Jones, Emily J. H.

AU - Gliga, Teodora

AU - Smith, Tim J.

AU - Charman, Tony

AU - Johnson, Mark H.

AU - BASIS Team

AU - Baron-cohen, Simon

AU - Bedford, Rachael

AU - Bolton, Patrick

AU - Chandler, Susie

AU - Davies, Kim

AU - Fernandes, Janice

AU - Garwood, Holly

AU - Hudry, Kristelle

AU - Maris, Helen

AU - Pasco, Greg

AU - Pickles, Andrew

AU - Ribiero, Helena

AU - Tucker, Leslie

AU - Volein, Agnes

PY - 2015/2/6

Y1 - 2015/2/6

N2 - Little is known about how spontaneous attentional deployment differs on a millisecond-level scale in the early development of autism spectrum disorders (ASD). We measured fine-grained eye movement patterns in 6-to 9-month-old infants at high or low familial risk (HR/LR) of ASD while they viewed static images. We observed shorter fixation durations (i.e. the time interval between saccades) in HR than LR infants. Preliminary analyses indicate that these results were replicated in a second cohort of infants. Fixation durations were shortest in those infants who went on to receive an ASD diagnosis at 36 months. While these findings demonstrate early-developing atypicality in fine-grained measures of attentional deployment early in the etiology of ASD, the specificity of these effects to ASD remains to be determined.

AB - Little is known about how spontaneous attentional deployment differs on a millisecond-level scale in the early development of autism spectrum disorders (ASD). We measured fine-grained eye movement patterns in 6-to 9-month-old infants at high or low familial risk (HR/LR) of ASD while they viewed static images. We observed shorter fixation durations (i.e. the time interval between saccades) in HR than LR infants. Preliminary analyses indicate that these results were replicated in a second cohort of infants. Fixation durations were shortest in those infants who went on to receive an ASD diagnosis at 36 months. While these findings demonstrate early-developing atypicality in fine-grained measures of attentional deployment early in the etiology of ASD, the specificity of these effects to ASD remains to be determined.

U2 - 10.1038/srep08284

DO - 10.1038/srep08284

M3 - Article

SN - 2045-2322

VL - 5

JO - Scientific Reports

JF - Scientific Reports

M1 - 8284

ER -

Shorter spontaneous fixation durations in infants with later emerging autism

Abstract

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