Spatial and temporal regulation of integrin signalling during cell migration

Timothy M. E. Scales; Madeline Parsons

doi:10.1016/j.ceb.2011.05.008

Spatial and temporal regulation of integrin signalling during cell migration

Timothy M. E. Scales, Madeline Parsons

King's College London

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Highlights:
► Integrin-based adhesions are dynamic signalling hubs. ► Integrin activation molecules play a key role in regulating adhesion assembly. ► Adhesions vary in size and stability depending on molecular composition. ► Integrins trigger specific signalling to promote adhesion turnover. ► Adhesion turnover is temporally regulated depending on subcellular localisation.

Original language	English
Pages (from-to)	562-568
Number of pages	7
Journal	Current Opinion in Cell Biology
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/j.ceb.2011.05.008
Publication status	Published - Oct 2011

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10.1016/j.ceb.2011.05.008

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title = "Spatial and temporal regulation of integrin signalling during cell migration",

abstract = "Highlights:► Integrin-based adhesions are dynamic signalling hubs. ► Integrin activation molecules play a key role in regulating adhesion assembly. ► Adhesions vary in size and stability depending on molecular composition. ► Integrins trigger specific signalling to promote adhesion turnover. ► Adhesion turnover is temporally regulated depending on subcellular localisation.",

author = "Scales, {Timothy M. E.} and Madeline Parsons",

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AU - Parsons, Madeline

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AB - Highlights:► Integrin-based adhesions are dynamic signalling hubs. ► Integrin activation molecules play a key role in regulating adhesion assembly. ► Adhesions vary in size and stability depending on molecular composition. ► Integrins trigger specific signalling to promote adhesion turnover. ► Adhesion turnover is temporally regulated depending on subcellular localisation.

U2 - 10.1016/j.ceb.2011.05.008

DO - 10.1016/j.ceb.2011.05.008

M3 - Article

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VL - 23

SP - 562

EP - 568

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 5

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Spatial and temporal regulation of integrin signalling during cell migration

Abstract

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