Abstract
Interferometric scattering (iSCAT) microscopy enables high speed and label-free detection of individual molecules and small nanoparticles. Here we apply point spread function engineering to provide adaptive control of iSCAT images using spatial light modulation. With this approach we demonstrate improved dynamic spatial filtering, real-time background subtraction, focus control, and signal modulation based on sample orientation.
| Original language | English |
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| Journal | Journal of Microscopy |
| Publication status | Accepted/In press - 22 Jul 2024 |