TY - JOUR
T1 - Specification of tissue-resident macrophages during organogenesis
AU - Mass, Elvira
AU - Ballesteros, Ivan
AU - Farlik, Matthias
AU - Halbritter, Florian
AU - Günther, Patrick
AU - Crozet, Lucile
AU - Jacome-Galarza, Christian E.
AU - Händler, Kristian
AU - Klughammer, Johanna
AU - Kobayashi, Yasuhiro
AU - Gomez Perdiguero, Elisa
AU - Schultze, Joachim L.
AU - Beyer, Marc
AU - Bock, Christoph
AU - Geissmann, Frederic
PY - 2016/9/9
Y1 - 2016/9/9
N2 - Tissue-resident macrophages support embryonic development and tissue homeostasis and repair. The mechanisms that control their differentiation remain unclear. We report here that erythro-myeloid progenitors in mice generate premacrophages (pMacs) that simultaneously colonize the whole embryo from embryonic day 9.5 in a chemokine-receptor-dependent manner. The core macrophage program initiated in pMacs is rapidly diversified as expression of transcriptional regulators becomes tissue-specific in early macrophages. This process appears essential for macrophage specification and maintenance, as inactivation of Id3 impairs the development of liver macrophages and results in selective Kupffer cell deficiency in adults. We propose that macrophage differentiation is an integral part of organogenesis, as colonization of organ anlagen by pMacs is followed by their specification into tissue macrophages, hereby generating the macrophage diversity observed in postnatal tissues.
AB - Tissue-resident macrophages support embryonic development and tissue homeostasis and repair. The mechanisms that control their differentiation remain unclear. We report here that erythro-myeloid progenitors in mice generate premacrophages (pMacs) that simultaneously colonize the whole embryo from embryonic day 9.5 in a chemokine-receptor-dependent manner. The core macrophage program initiated in pMacs is rapidly diversified as expression of transcriptional regulators becomes tissue-specific in early macrophages. This process appears essential for macrophage specification and maintenance, as inactivation of Id3 impairs the development of liver macrophages and results in selective Kupffer cell deficiency in adults. We propose that macrophage differentiation is an integral part of organogenesis, as colonization of organ anlagen by pMacs is followed by their specification into tissue macrophages, hereby generating the macrophage diversity observed in postnatal tissues.
UR - http://www.scopus.com/inward/record.url?scp=85015601341&partnerID=8YFLogxK
U2 - 10.1126/science.aaf4238
DO - 10.1126/science.aaf4238
M3 - Article
C2 - 27492475
VL - 353
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
IS - 6304
ER -