Subchronic and chronic PCP treatment produces temporally distinct deficits in attentional set shifting and prepulse inhibition in rats

Alice Egerton; Lee Reid; Sandie McGregor; Susan M Cochran; Brian J Morris; Judith A Pratt

doi:10.1007/s00213-008-1071-5

Subchronic and chronic PCP treatment produces temporally distinct deficits in attentional set shifting and prepulse inhibition in rats

Alice Egerton, Lee Reid, Sandie McGregor, Susan M Cochran, Brian J Morris, Judith A Pratt

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

Abstract

We have previously demonstrated that subchronic (five daily administrations of 2.6 mg/kg PCP) and chronic intermittent administration of 2.6 mg/kg PCP to rats produces hypofrontality and other neurochemical changes akin to schizophrenia pathology (Cochran et al., Neuropsychopharmacology, 28:265-275, 2003).

Original language	English
Pages (from-to)	37-49
Number of pages	13
Journal	Psychopharmacology
Volume	198
Issue number	1
DOIs	https://doi.org/10.1007/s00213-008-1071-5
Publication status	Published - May 2008

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10.1007/s00213-008-1071-5

Cite this

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title = "Subchronic and chronic PCP treatment produces temporally distinct deficits in attentional set shifting and prepulse inhibition in rats",

abstract = "We have previously demonstrated that subchronic (five daily administrations of 2.6 mg/kg PCP) and chronic intermittent administration of 2.6 mg/kg PCP to rats produces hypofrontality and other neurochemical changes akin to schizophrenia pathology (Cochran et al., Neuropsychopharmacology, 28:265-275, 2003).",

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AU - Reid, Lee

AU - McGregor, Sandie

AU - Cochran, Susan M

AU - Morris, Brian J

AU - Pratt, Judith A

PY - 2008/5

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AB - We have previously demonstrated that subchronic (five daily administrations of 2.6 mg/kg PCP) and chronic intermittent administration of 2.6 mg/kg PCP to rats produces hypofrontality and other neurochemical changes akin to schizophrenia pathology (Cochran et al., Neuropsychopharmacology, 28:265-275, 2003).

U2 - 10.1007/s00213-008-1071-5

DO - 10.1007/s00213-008-1071-5

M3 - Article

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SP - 37

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JO - Psychopharmacology

JF - Psychopharmacology

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