Substance use, medication adherence and outcome one year following a first episode of psychosis

Marco Colizzi; Elena Carra; Sara Fraietta; John Lally; Diego Quattrone; Stefania Bonaccorso; Valeria Mondelli; Olesya Ajnakina; Paola Dazzan; Antonella Trotta; Lucia Sideli; Anna Kolliakou; Fiona Gaughran; Mizanur Khondoker; Anthony S. David; Robin M. Murray; James H. MacCabe; Marta Di Forti

doi:10.1016/j.schres.2015.11.016

Substance use, medication adherence and outcome one year following a first episode of psychosis

Marco Colizzi, Elena Carra, Sara Fraietta, John Lally, Diego Quattrone, Stefania Bonaccorso, Valeria Mondelli, Olesya Ajnakina, Paola Dazzan, Antonella Trotta, Lucia Sideli, Anna Kolliakou, Fiona Gaughran, Mizanur Khondoker, Anthony S. David, Robin M. Murray, James H. MacCabe, Marta Di Forti^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

464 Downloads (Pure)

Abstract

Both substance use and poor medication adherence are associated with poor outcome in psychosis. To clarify the contributions of substance use and poor medication adherence to poor outcome in the year following a first episode of psychosis, 205 patients were evaluated for use of tobacco, alcohol, cannabis and stimulants at their psychosis onset, and in a 1-year follow-up. Data on medication adherence and symptom remission were also collected. Patients had high rates of overall substance use before (37-65%) and after psychosis onset (45-66%). 44% showed poor medication adherence and 55% did not reach remission from psychosis. Nicotine dependence and cannabis use after psychosis onset significantly predicted both poor medication adherence and non-remission, and poor medication adherence mediated the effects of these substances on non-remission. In conclusion, medication adherence lies on the causal pathway between nicotine dependence and cannabis on the one hand and non-remission on the other.

Original language	English
Pages (from-to)	311-317
Number of pages	7
Journal	Schizophrenia Research
Volume	170
Issue number	2-3
Early online date	21 Dec 2015
DOIs	https://doi.org/10.1016/j.schres.2015.11.016
Publication status	Published - 1 Feb 2016

Keywords

Cannabis use
First episode psychosis
Medication adherence
Nicotine dependence
Remission
Substance use

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.schres.2015.11.016

Substance use, medication adherence_COLIZZI_Publishedonline21December2015_GREEN AAMAccepted author manuscript, 309 KBLicence: CC BY-NC-ND

Cite this

Colizzi, M., Carra, E., Fraietta, S., Lally, J., Quattrone, D., Bonaccorso, S., Mondelli, V., Ajnakina, O., Dazzan, P., Trotta, A., Sideli, L., Kolliakou, A., Gaughran, F., Khondoker, M., David, A. S., Murray, R. M., MacCabe, J. H., & Di Forti, M. (2016). Substance use, medication adherence and outcome one year following a first episode of psychosis. Schizophrenia Research, 170(2-3), 311-317. https://doi.org/10.1016/j.schres.2015.11.016

@article{bed848d34ba24335a8e2412ce3343350,

title = "Substance use, medication adherence and outcome one year following a first episode of psychosis",

abstract = "Both substance use and poor medication adherence are associated with poor outcome in psychosis. To clarify the contributions of substance use and poor medication adherence to poor outcome in the year following a first episode of psychosis, 205 patients were evaluated for use of tobacco, alcohol, cannabis and stimulants at their psychosis onset, and in a 1-year follow-up. Data on medication adherence and symptom remission were also collected. Patients had high rates of overall substance use before (37-65%) and after psychosis onset (45-66%). 44% showed poor medication adherence and 55% did not reach remission from psychosis. Nicotine dependence and cannabis use after psychosis onset significantly predicted both poor medication adherence and non-remission, and poor medication adherence mediated the effects of these substances on non-remission. In conclusion, medication adherence lies on the causal pathway between nicotine dependence and cannabis on the one hand and non-remission on the other.",

keywords = "Cannabis use, First episode psychosis, Medication adherence, Nicotine dependence, Remission, Substance use",

author = "Marco Colizzi and Elena Carra and Sara Fraietta and John Lally and Diego Quattrone and Stefania Bonaccorso and Valeria Mondelli and Olesya Ajnakina and Paola Dazzan and Antonella Trotta and Lucia Sideli and Anna Kolliakou and Fiona Gaughran and Mizanur Khondoker and David, {Anthony S.} and Murray, {Robin M.} and MacCabe, {James H.} and {Di Forti}, Marta",

year = "2016",

month = feb,

day = "1",

doi = "10.1016/j.schres.2015.11.016",

language = "English",

volume = "170",

pages = "311--317",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

number = "2-3",

}

Colizzi, M, Carra, E, Fraietta, S, Lally, J , Quattrone, D , Bonaccorso, S , Mondelli, V , Ajnakina, O , Dazzan, P , Trotta, A, Sideli, L, Kolliakou, A , Gaughran, F , Khondoker, M , David, AS , Murray, RM , MacCabe, JH & Di Forti, M 2016, 'Substance use, medication adherence and outcome one year following a first episode of psychosis', Schizophrenia Research, vol. 170, no. 2-3, pp. 311-317. https://doi.org/10.1016/j.schres.2015.11.016

TY - JOUR

T1 - Substance use, medication adherence and outcome one year following a first episode of psychosis

AU - Colizzi, Marco

AU - Carra, Elena

AU - Fraietta, Sara

AU - Lally, John

AU - Quattrone, Diego

AU - Bonaccorso, Stefania

AU - Mondelli, Valeria

AU - Ajnakina, Olesya

AU - Dazzan, Paola

AU - Trotta, Antonella

AU - Sideli, Lucia

AU - Kolliakou, Anna

AU - Gaughran, Fiona

AU - Khondoker, Mizanur

AU - David, Anthony S.

AU - Murray, Robin M.

AU - MacCabe, James H.

AU - Di Forti, Marta

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Both substance use and poor medication adherence are associated with poor outcome in psychosis. To clarify the contributions of substance use and poor medication adherence to poor outcome in the year following a first episode of psychosis, 205 patients were evaluated for use of tobacco, alcohol, cannabis and stimulants at their psychosis onset, and in a 1-year follow-up. Data on medication adherence and symptom remission were also collected. Patients had high rates of overall substance use before (37-65%) and after psychosis onset (45-66%). 44% showed poor medication adherence and 55% did not reach remission from psychosis. Nicotine dependence and cannabis use after psychosis onset significantly predicted both poor medication adherence and non-remission, and poor medication adherence mediated the effects of these substances on non-remission. In conclusion, medication adherence lies on the causal pathway between nicotine dependence and cannabis on the one hand and non-remission on the other.

AB - Both substance use and poor medication adherence are associated with poor outcome in psychosis. To clarify the contributions of substance use and poor medication adherence to poor outcome in the year following a first episode of psychosis, 205 patients were evaluated for use of tobacco, alcohol, cannabis and stimulants at their psychosis onset, and in a 1-year follow-up. Data on medication adherence and symptom remission were also collected. Patients had high rates of overall substance use before (37-65%) and after psychosis onset (45-66%). 44% showed poor medication adherence and 55% did not reach remission from psychosis. Nicotine dependence and cannabis use after psychosis onset significantly predicted both poor medication adherence and non-remission, and poor medication adherence mediated the effects of these substances on non-remission. In conclusion, medication adherence lies on the causal pathway between nicotine dependence and cannabis on the one hand and non-remission on the other.

KW - Cannabis use

KW - First episode psychosis

KW - Medication adherence

KW - Nicotine dependence

KW - Remission

KW - Substance use

UR - http://www.scopus.com/inward/record.url?scp=84950284719&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2015.11.016

DO - 10.1016/j.schres.2015.11.016

M3 - Article

SN - 0920-9964

VL - 170

SP - 311

EP - 317

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 2-3

ER -

Substance use, medication adherence and outcome one year following a first episode of psychosis

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this