Super-resolution imaging of microbubble contrast agents

Many diseases, such as those associated with diabetes, coronary heart disease, and the growth and metastasis of tumors exhibit architectural changes in microvascular structure, as well as variations in vascular flow. Current clinical imaging modalities such as MRI, PET, CT and Ultrasound cannot easily resolve the microvasculature. Although optical light microscopy is able to resolve structures on the scale of microvasculature, the restricted imaging depth of this approach is a major limitation. Thus, there is a clinical need for the development of new imaging techniques that can fill this resolution gap.